Inflammasome Signaling and Bacterial Infections

  • Steffen Backert

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 397)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Hanne Dubois, Andy Wullaert, Mohamed Lamkanfi
    Pages 1-22
  3. Shauna M. Crowley, Leigh A. Knodler, Bruce A. Vallance
    Pages 43-67
  4. Naomi H. Philip, Erin E. Zwack, Igor E. Brodsky
    Pages 69-90
  5. Anna-Karin Hermansson, Ida Paciello, Maria Lina Bernardini
    Pages 91-115
  6. Suneesh Kumar Pachathundikandi, Anne Müller, Steffen Backert
    Pages 117-131
  7. Ursula Schell, Sylvia Simon, Hubert Hilbi
    Pages 161-181
  8. Manoranjan Sahoo, Louis Lantier, Fabio Re
    Pages 199-214
  9. Pierre Wallet, Brice Lagrange, Thomas Henry
    Pages 229-256

About this book


This volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in response to infection with important bacterial model organisms and the corresponding disease pathologies. The first chapters review new insights into the assembly and structures of inflammasome components and emphasize general strategies of up- and downstream signaling events. In addition, the authors specifically discuss the composition and activity of inflammasomes during infection with various gut pathogens (Salmonella, Shigella, Yersinia, Listeria and Helicobacter), respiratory pathogens (Mycobacterium, Legionella, Burkholderia and Streptococcus) as well as skin and soft tissue pathogens (Francisella and Staphylococcus). The discoveries presented provide a better understanding of the cellular and molecular biology of inflammasomes, which will pinpoint important new therapeutic targets for the treatment and prevention of multiple infectious diseases in the future. It is a valuable resource for students, scientists and clinicians, providing up-to-date information on this emerging research topic.


Inflammasome biology Salmonella enterica Yersinia pestis Shigella flexneri Helicobacter pylori LIsteria monocytogenes Legionella pneumophila Mycobacterium Burkholderia pseudomallei Streptococcus pneumoniae Franciscella tularensis Staphylococcus aureus NLR inflammasome Cytosolic bacteriolysis Tumor immunotherapy

Editors and affiliations

  • Steffen Backert
    • 1
  1. 1.Department of Biology, Division of Microbiology Friedrich Alexander University Erlangen/NurembergErlangenGermany

Bibliographic information

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