Increasing the Therapeutic Ratio of Radiotherapy

  • Philip J. Tofilon
  • Kevin Camphausen

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Thomas J. Hayman, Joseph N. Contessa
    Pages 35-55
  3. Elizabeth I. Spehalski, Philip J. Tofilon, Kevin Camphausen
    Pages 57-78
  4. Su I. Chung, DeeDee K. Smart, Eun Joo Chung, Deborah E. Citrin
    Pages 79-102
  5. Sarwat Naz, Murali C. Krishna, James B. Mitchell
    Pages 103-134
  6. Aaron M. Laine, Zabi Wardak, Michael R. Folkert, Robert D. Timmerman
    Pages 171-202
  7. Adam Gladwish, Kathy Han
    Pages 203-239
  8. Ajlan Al Zaki, David Cormode, Andrew Tsourkas, Jay F. Dorsey
    Pages 241-265
  9. Back Matter
    Pages 267-280

About this book


Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy.

In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations.

Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection).

Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.


DNA DNA repair Radiotherapy Therapeutic Ratio Tumors

Editors and affiliations

  • Philip J. Tofilon
    • 1
  • Kevin Camphausen
    • 2
  1. 1.Radiation Oncology BranchNational Cancer InstituteBethesdaUSA
  2. 2.1Radiation Oncology BranchNational Cancer InstituteBethesdaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Humana Press, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-40852-1
  • Online ISBN 978-3-319-40854-5
  • Series Print ISSN 2196-9906
  • Series Online ISSN 2196-9914
  • Buy this book on publisher's site
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