Advertisement

© 2016

Systemic Vasculitides: Current Status and Perspectives

  • Franco Dammacco
  • Domenico Ribatti
  • Angelo Vacca
Book

Table of contents

  1. Front Matter
    Pages i-xi
  2. Biology of Blood Vessels, Experimental Models and Nomenclature of Vasculitides

    1. Front Matter
      Pages 1-1
    2. Domenico Ribatti
      Pages 3-8
    3. Domenico Ribatti, Franco Dammacco
      Pages 9-13
    4. J. Charles Jennette, Ronald J. Falk, Marco A. Alba
      Pages 15-28
    5. Joice M. F. M. Belem, Bruna Savioli, Alexandre Wagner Silva de Souza
      Pages 29-41
    6. Giuseppe A. Ramirez, Angelo A. Manfredi
      Pages 43-50
  3. Primary Systemic Vasculitides

    1. Front Matter
      Pages 51-51
    2. Enrico Tombetti, Elena Baldissera, Angelo A. Manfredi, Maria Grazia Sabbadini
      Pages 53-62
    3. Silvia Laura Bosello, Elisa Gremese, Angela Carbonella, Federico Parisi, Francesco Cianci, Gianfranco Ferraccioli
      Pages 79-96
    4. F. David Carmona, Javier Martín
      Pages 97-108
    5. Franco Dammacco, Angelo Vacca
      Pages 109-118
    6. Franco Dammacco, Sebastiano Cicco, Domenico Ribatti, Angelo Vacca
      Pages 119-128
    7. Renato Alberto Sinico, Paolo Bottero
      Pages 129-139
    8. Adrian Schreiber, Mira Choi
      Pages 141-158
    9. James Ritchie, Timothy Reynolds, Joanna C. Robson
      Pages 159-171
    10. Fernanda Falcini, Gemma Lepri
      Pages 173-187
    11. Nicolò Pipitone, Carlo Salvarani
      Pages 189-196
    12. Michele Rossini, Annamaria Di Palma, Vito Racanelli, Francesco Dammacco, Loreto Gesualdo
      Pages 197-202

About this book

Introduction

The systemic vasculitides,includinglarge, medium, small, and variable vessel vasculitis,have been the focus of intensive basic and clinical investigations over the last twodecades. Among theimportant advances stemming from these efforts are new definitions, classifications, and diagnostic criteria for the different classes of vasculitis; the addition of anti-neutrophil cytoplasmic autoantibodies as a new criterion for classifying vasculitis; the recognition of  the viral etiology of conditions such as cryoglobulinemic vasculitis and polyarteritis nodosa; an appreciation of thebroad spectrum of clinical manifestations and potentially devastating complicationsassociated with vasculitis; the many features and remarkable clinical heterogeneity of IgG4-related, immune-mediated diseases; and the proposal of intriguing pathogenetic hypotheses for certain chronic, relapsing vasculitides.

This improved understanding of the systemic vasculitides has been accompanied by a trend away from the use of eponyms for these conditions; thus, established terms such as Wegener’s granulomatosis and Churg-Strauss syndrome have been replacedby the more descriptive definitions “granulomatosis with polyangiitis” and “eosinophilic granulomatosis with polyangiitis,” respectively.

Additional clinical laboratory tests,rapidly developing imaging techniques that can assess inflammation, especially in large-vessel vasculitis, and artificial neural network approaches will no doubt bring a wealth of informationthat ultimately leads to the identification of novel disease biomarkers. Expected applications include the identification of individuals at increased risk ofrelapsewho would benefit from patient-tailored therapy. Although the conventional combination of glucocorticoids and immunosuppressive drugs is effective in the treatment of a large proportion of vasculitic disorders, safer medications, with fewer side effects, are being developed, includingseveral biological agents now being closely evaluated in multi-center studies.

This volume brings togethercomprehensive and up-to-date reviews written by experiencedscientists and clinicians from many countries. Its aim is toprovide readers with state-of-the-art knowledge of the major vasculitides and cutting-edge insights into their multi-faceted features. It is our hope that this book serves as a valuable and stimulating resourcefor basic and clinical researchers, specialists in related disciplines, as well as practicing physicians and advanced medical students interested in this fascinating branch of pathology.

 

Franco Dammacco, Domenico Ribatti, Angelo Vacca

Keywords

vasculitis glomerulonephritis purpura pulmonary infiltration ANCA

Editors and affiliations

  • Franco Dammacco
    • 1
  • Domenico Ribatti
    • 2
  • Angelo Vacca
    • 3
  1. 1.University of Bari Medical SchoolBariItaly
  2. 2.University of Bari Medical SchoolBariItaly
  3. 3.University of Bari Medical SchoolBariItaly

About the editors

Franco Dammacco is Emeritus Professor of Internal Medicine at the University of Bari Medical School and has been President of the Italian Society of Internal Medicine. His research and clinical interests include HCV-related cryoglobulinemic vasculitis, onco-hematology, connective tissue diseases and immunodeficiency syndromes. He is author or co-author of more than 470 papers and Editor-in-Chief of the journal Clinical and Experimental Medicine.

Domenico Ribatti is full Professor of Human Anatomy at the University of Bari Medical School. His main research topics are angiogenesis and anti-angiogenesis, with special emphasis for hematological malignancies, tumor microcirculation, and immunological competence.  He is author of over 650 papers  and 8 monographs.

Angelo Vacca is full Professor of Internal Medicine at the University of Bari Medical School and President of the Italian Society of Immunology, Clinical Immunology and Allergology. He is actively involved in research areas such as angiogenesis and tumor progression, multiple myeloma and related malignancies, biological markers of tumor invasion and metastasis, and controlled chemotherapy studies. On these topics he has published over 300 papers.

 

Bibliographic information

Industry Sectors
Biomedicine
Biotechnology
Health & Hospitals
Pharma