© 2017

Basic Science of PET Imaging

  • Magdy M. Khalil

Table of contents

  1. Front Matter
    Pages i-xix
  2. Physics, Radiation Safety and Dosimetry of PET

    1. Front Matter
      Pages 1-1
    2. Taher Hosny, Eman Al-Anezi, Magdy M. Khalil
      Pages 3-35
    3. Debbie Peet, Sue Edyvean
      Pages 37-64
    4. Michael G. Stabin
      Pages 65-76
  3. PET Chemistry and Regulation of PET Radiopharmaceuticals

    1. Front Matter
      Pages 77-77
    2. Stefano Boschi, Filippo Lodi
      Pages 79-103
    3. Filippo Lodi, Stefano Boschi
      Pages 105-126
    4. James R. Ballinger, Jacek Koziorowski
      Pages 127-143
  4. PET Physics and Instrumentation

    1. Front Matter
      Pages 171-171
    2. Srilalan Krishnamoorthy, Jeffrey P. Schmall, Suleman Surti
      Pages 173-197
    3. Magdy M. Khalil
      Pages 199-228
  5. PET Image Reconstruction, Processing and Quantitation

    1. Front Matter
      Pages 257-257
    2. Magdy M. Khalil
      Pages 303-322
    3. Hiroshi Watabe
      Pages 323-352
  6. PET Imaging Artifacts and Correction Techniques

    1. Front Matter
      Pages 353-353

About this book


This book offers a wide-ranging and up-to-date overview of the basic science underlying PET and
its preclinical and clinical applications in modern medicine. In addition, it provides the reader with a sound understanding of the scientific principles and use of PET in routine practice and biomedical imaging research. The opening sections address the fundamental physics, radiation safety, CT scanning dosimetry, and dosimetry of PET radiotracers, chemistry and regulation of PET radiopharmaceuticals, with information on labeling strategies, tracer quality control, and regulation of radiopharmaceutical production in Europe and the United States. PET physics and instrumentation are then discussed, covering the basic principles of PET and PET scanning systems, hybrid PET/CT and PET/MR imaging, system calibration, acceptance testing, and quality control. Subsequent sections focus on image reconstruction, processing, and quantitation in PET and hybrid PET and on imaging artifacts and correction techniques, with particular attention to partial volume correction and motion artifacts. The book closes by examining clinical applications of PET and hybrid PET and their physiological and/or molecular basis in conjunction with technical foundations in the disciplines of oncology, cardiology and neurology, PET in pediatric malignancy and its role in radiotherapy treatment planning. Basic Science of PET Imaging will meet the needs of nuclear medicine practitioners, other radiology specialists, and trainees in these fields.


Hybrid Imaging Molecular Imaging Motion Correction in PET PET Data Analysis PET Kinetics PET Physics and Instrumentation PET Radiopharmaceuticals PET Radiopharmacy PET/CT Quantitative PET Imaging: Radiation Dosimetry of PET imaging

Editors and affiliations

  • Magdy M. Khalil
    • 1
  1. 1.Medical Biophysics Department of Physics Faculty of ScienceHelwan UniversityCairoEgypt

About the editors

Magdy M. Khalil Ph.D., Medical Biophysics, Department of Physics, Faculty of Science, Helwan University, Cairo, Egypt. 

Bibliographic information

  • Book Title Basic Science of PET Imaging
  • Editors Magdy M. Khalil
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-40068-6
  • Softcover ISBN 978-3-319-82025-5
  • eBook ISBN 978-3-319-40070-9
  • Edition Number 1
  • Number of Pages XIX, 619
  • Number of Illustrations 50 b/w illustrations, 100 illustrations in colour
  • Topics Nuclear Medicine
    Diagnostic Radiology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Nuclear Medicine


“This superbly edited book provides a broad overview of the current basic scientific principles underlying positron emission tomography (PET) and its preclinical and clinical applications in medicine. … Several groups should find this book educational and useful, including students, experienced clinicians, and stakeholders in radiology, nuclear medicine, molecular imaging, medical physics, health physics, patient safety, administration, regulatory bodies, professional organizations, and agencies.” (Lawrence T. Dauer, Doody's Book Reviews, May, 2018)

“Khalil and colleagues should therefore be commended for compiling such a comprehensive text swiftly enough for it to be contemporary. It would provide an excellent grounding for a physicist, technologist, radiopharmacist or physician who has just entered the field. The clear print is illustrated with figures that really aid the readers’ understanding and are mostly of excellent quality, and in colour. … I would highly recommend this text … .”  (Dr. Heather Williams, RAD Magazine, August, 2017)