Modified Nucleic Acids in Biology and Medicine

  • Stefan Jurga
  • Volker A. Erdmann (Deceased)
  • Jan Barciszewski

Part of the RNA Technologies book series (RNATECHN)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Adrian Gabriel Torres, Lluís Ribas de Pouplana
    Pages 1-26
  3. Shawn M. Lyons, Marta M. Fay, Pavel Ivanov
    Pages 27-54
  4. Kyla M. Frohlich, Kathryn L. Sarachan, Gabrielle C. Todd, Maria Basanta-Sanchez, Ville Y. P. Väre, Paul F. Agris
    Pages 91-130
  5. Hiroshi Kasai, Kazuaki Kawai
    Pages 147-185
  6. Ulf Birkedal, Nicolai Krogh, Kasper Langebjerg Andersen, Henrik Nielsen
    Pages 187-205
  7. Suliman Boulos, Ehud Razin, Hovav Nechushtan, Inbal Rachmin
    Pages 207-219
  8. Patryk Konieczny, Ewa Stepniak-Konieczna, Krzysztof Sobczak
    Pages 243-271
  9. Kass A. Jobst, Alexander Klenov, Kira C. M. Neller, Katalin A. Hudak
    Pages 273-297
  10. Ilya Dovydenko, Alya Venyaminova, Dmitrii Pyshnyi, Ivan Tarassov, Nina Entelis
    Pages 319-337
  11. Ellen Gyssels, Nathalie De Laet, Emily Lumley, Annemieke Madder
    Pages 339-369
  12. Masayasu Kuwahara, Kenta Hagiwara, Hiroaki Ozaki
    Pages 429-453

About this book

Introduction

This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties.

The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression.

Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides.

This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.

 

Keywords

RNA and DNA acids biomarkers modified nucleic acids molecular diagnostics nucleic acid biological chemistry

Editors and affiliations

  • Stefan Jurga
    • 1
  • Volker A. Erdmann (Deceased)
    • 2
  • Jan Barciszewski
    • 3
  1. 1.Nanobiomedical CenterAdam Mickiewicz UniversityPoznańPoland
  2. 2.Formerly at Institute of Chemistry and BiochemistryFree University BerlinBerlinGermany
  3. 3.Institute of the Bioorganic Chemistry of the Polish Academy of SciencesPoznańPoland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-34175-0
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-34173-6
  • Online ISBN 978-3-319-34175-0
  • Series Print ISSN 2197-9731
  • Series Online ISSN 2197-9758
  • About this book
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