© 2016

Genome Editing

  • Kursad Turksen

Table of contents

  1. Front Matter
    Pages i-ix
  2. Stephane Pelletier
    Pages 1-29
  3. Davide Seruggia, Lluis Montoliu
    Pages 31-43
  4. Knut Woltjen, Fabian Oceguera-Yanez, Harunobu Kagawa, Shin-Il Kim
    Pages 45-64
  5. Channabasavaiah B. Gurumurthy, Rolen M. Quadros, Masahiro Sato, Tomoji Mashimo, K. C. Kent Lloyd, Masato Ohtsuka
    Pages 65-77
  6. Samvel Avagyan, Kyle Sylakowski, Uma Lakshmipathy
    Pages 93-106
  7. Vittavat Termglinchan, Ioannis Karakikes, Timon Seeger, Joseph C. Wu
    Pages 107-126
  8. Sally Justus, Andrew Zheng, Yi-Ting Tsai, Wen-Hsuan Wu, Chun-Wei Hsu, Wei-Pu Wu et al.
    Pages 149-162
  9. Back Matter
    Pages 163-166

About this book


This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of controversies and future directions.

Genome Editing is an essential, of-the-moment contribution to this rapidly growing field. Drawing from a wealth of international perspectives, it presents novel techniques and applications for the engineering of the human genome. This book is essential reading for all clinicians and researchers in stem cells, regenerative medicine, genomics, biochemical and biomedical engineering- especially those interested in learning more about genome editing and applying it in a targeted, specific way.


CRISPR ESC iPSC nucleases stem cells

Editors and affiliations

  • Kursad Turksen
    • 1
  1. 1.OttawaCanada

About the editors

Kursad Turksen received his Ph.D. from the University of Toronto in Toronto, Canada in the area of osteoprogenitor biology and cell selection methodologies. He completed his postdoctoral training at the Howard Hughes Medical Institute, University of Chicago, in Chicago, Illinois, studying epidermal biology through use of genetically-altered mouse models. He joined the Ottawa Hospital Research Institute in Ottawa, Canada [previously known as the Loeb Research Institute] where he rose to the position of Senior Scientist in the Division of Regenerative Medicine. His research interests focus on stem cell biology, with a particular interest in the Claudin family of tight junction proteins and their role in epidermal lineage commitment and progression during development in health and disease. Dr. Turksen is currently Editor in Chief of the Springer journal Stem Cell Reviews and Reports in addition to serving as series editor for the Springer series Stem Cell Biology and Regenerative Medicine.

Bibliographic information

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