© 2016

Interventional Therapies for Secondary and Essential Hypertension

  • Costas Tsioufis
  • Roland E. Schmieder
  • Giuseppe Mancia


  • Focuses solely on interventional treatments of hypertension (secondary and essential)

  • Offers a clear review of relevant procedures and guidance on their applications

  • Includes helpful explanatory diagrams and treatment algorithms


Table of contents

  1. Front Matter
    Pages i-x
  2. Interventions for Secondary Hypertension

    1. Front Matter
      Pages 1-1
    2. Thomas Zeller, Ulrich Beschorner, Elias Noory
      Pages 3-27
    3. Michael Doumas, Stella Douma
      Pages 29-55
    4. Philippe van de Borne
      Pages 57-70
    5. Maria Boutsikou, Anselm Uebing, Michael A. Gatzoulis
      Pages 71-86
  3. Adjunctive Therapies

    1. Front Matter
      Pages 87-87
    2. Gianfranco Parati, Carolina Lombardi, Juan Eugenio Ochoa
      Pages 89-118
  4. Interventions for Essential Hypertension

    1. Front Matter
      Pages 119-119
    2. Mónica Domenech, Antonio Coca
      Pages 121-127
    3. Enrico Agabiti Rosei, Massimo Salvetti
      Pages 129-137
    4. Reinhold Kreutz, Engi Abdel-Hady Algharably
      Pages 157-178
    5. Michel Burnier, Gregoire Wuerzner
      Pages 179-192
    6. Atul Pathak, Benjamin Honton, Mel Lobo
      Pages 193-200
    7. Vasilios Papademetriou, Michael Doumas, Costas Tsioufis, Venkatesh K. Raman
      Pages 201-213
    8. Ina Zivanovic, Sebastian Ewen, Michael Böhm, Felix Mahfoud
      Pages 215-230
    9. Costas Thomopoulos, Alexandros Kasiakogias, Ioannis Kallikazaros, Costas Tsioufis
      Pages 231-243
    10. Costas P. Tsioufis, Dimitrios Tousoulis
      Pages 245-265

About this book


This book aims to describe the role of interventional therapies in various forms of secondary hypertension and to explain the ability of such approaches to address unmet needs in the setting of uncontrolled essential hypertension. The coverage encompasses interventions in the full range of relevant conditions, including the various specific pathologies responsible for secondary hypertension, such as renal artery stenosis, coarctation of the aorta, and adrenal tumors. In each case, up-to-date information is presented on indications, procedural aspects, and patient follow-up. A further focus is the most recent knowledge on the use of invasive neuromodulation, such as renal sympathetic denervation and baroreflex stimulation. The text is supplemented by helpful explanatory diagrams and treatment algorithms. A comprehensive clinical guide of this nature has to date been absent from the literature. The book will be of interest to clinicians managing hypertensive patients, researchers investigating advanced hypertension management, and students on cardiology courses.


Resistant hypertension Secondary hypertension Renal artery stenosis Hyperaldosteronism Pheochromocytoma Sleep apnea Neuromodulation Renal denervation Carotid baroreceptors

Editors and affiliations

  • Costas Tsioufis
    • 1
  • Roland E. Schmieder
    • 2
  • Giuseppe Mancia
    • 3
  1. 1.First Cardiology ClinicNational and Kapodistrian University of AthensAthensGreece
  2. 2.Department of Nephrology and HypertensionUniversity Hospital Friedrich-Alexander University Erlangen-NürnbergErlangenGermany
  3. 3.IRCCS Istituto Auxologico ItalianoUniversity Milano-BicoccaMilano MonzaItaly

About the editors

Costas Tsioufis is Associate Professor of Cardiology in the 1st University Cardiology Clinic, Hippokration Hospital, Athens, Greece and Head of the Hypertension Unit of the same institute. He is currently secretary of the European Society of Hypertension and president elect of the Hellenic Cardiological Society. Professor Tsioufis research interests include hypertensive target organ damage with specific interest in microalbuminuria and renal dysfunction, left ventricular hypertrophy and arterial stiffness.  He has a special interest in the novel interventional therapies of hypertension and he is involved in major clinical trials regarding renal sympathetic denervation. In the field on Interventional Cardiology, his research has been focused on the assessment of coronary blood flow reserve and the pathophysiology of the vulnerable atherosclerotic plaque.

Roland Schmieder is a Professor of Internal Medicine, Nephrology and Hypertension, Head of the Clinical Research Centre of the Department of Nephrology and Hypertension at the University Hospital Erlangen, Germany. He also directs the Institute of Preventative Medicine at the University Erlangen-Nürnberg and the Community Hospital Nürnberg. He has served as council member and vice president of the European Society of Hypertension and is currently a member of the Council of the International Society of Hypertension. Professor Schmieder has extensive experience in the execution of human clinical trials and his research interests include nephrology, hypertension, diabetes, non-invasive cardiology and vascular medicine. He is an advisor and steering board member of several European and international multicenter studies.

Giuseppe Mancia is Professor Emeritus of the University of Milano-Bicocca and served as Professor of Medicine and Head of First Division of Medicine at the San Gerardo Hospital, Italy. He is executive officer of the European Society of Hypertension and Chair of the ESH Educational Committee. Prof. Mancia has served as President of the European Society of Clinical Investigation, as President of the Italian Society of Hypertension and as President of the European Society of Hypertension, the International Society of Hypertension, and member 'ex officio' of the Executive Scientific Council of the American Society of Hypertension among other. Dr. Mancia's research interests are pathophysiology, diagnosis and therapy of hypertension, heart failure, coronary and other cardiovascular diseases. His expertise includes ambulatory blood pressure monitoring, neural control of the circulation, large artery mechanics and clinical trials.

Bibliographic information

  • Book Title Interventional Therapies for Secondary and Essential Hypertension
  • Editors Costas Tsioufis
    Roland E. Schmieder
    Giuseppe Mancia
  • Series Title Updates in Hypertension and Cardiovascular Protection
  • Series Abbreviated Title Updates in Hypertension and Cardiovascular Protection
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-34140-8
  • Softcover ISBN 978-3-319-81685-2
  • eBook ISBN 978-3-319-34141-5
  • Series ISSN 2366-4606
  • Series E-ISSN 2366-4614
  • Edition Number 1
  • Number of Pages X, 363
  • Number of Illustrations 6 b/w illustrations, 13 illustrations in colour
  • Topics Cardiology
    Vascular Surgery
    Cardiac Surgery
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology


“An overview of the role of interventional therapies in the treatment of hypertension, this book includes sections for both essential and secondary hypertension and discusses adjunctive therapies. The purpose is to provide trainees and clinicians with an overview of interventional therapies in the treatment of essential and secondary hypertension. This book will be most helpful for clinicians and trainees in the fields of cardiology, family practice, and internal medicine.” (Jennifer A. Davis, Doody's Book Reviews, December, 2016)