© 2017

Prenatal Diagnosis of Orofacial Malformations

  • Gabriele Tonni
  • Waldo Sepulveda
  • Amy E. Wong

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Prenatal Diagnosis of Orofacial Malformations

    1. Front Matter
      Pages 1-1
    2. Gabriele Tonni, Waldo Sepulveda, Amy E. Wong
      Pages 3-8
    3. Arie Koifman, Susan Blaser, David Chitayat
      Pages 9-17
    4. Waldo Sepulveda, Amy E. Wong, Pilar Martinez-Ten, Gabriele Tonni
      Pages 19-41
    5. Pilar Martínez-Ten, Waldo Sepulveda, Amy E. Wong, Gabriele Tonni
      Pages 43-59
    6. Pilar Martínez-Ten, Waldo Sepulveda, Gabriele Tonni
      Pages 61-79
    7. Gabriele Tonni, Marcella Palmisano, Roberta Granese, Maria Paola Bonasoni
      Pages 81-104
    8. Edward Araujo Júnior, Eduardo Felix Martins Santana, Gabriele Tonni, Amy E. Wong, Waldo Sepulveda
      Pages 105-118
    9. Francisco Sepulveda, Gerlinde M. Gruber, Daniela Prayer
      Pages 119-130
    10. J. Ciaran Hutchinson, Neil J. Sebire
      Pages 143-156
    11. Fabio Xerfan Nahas, Natasha Sallum, Lydia Masako Ferreira
      Pages 157-162
  3. Interesting Cases and Rare Syndromes

    1. Front Matter
      Pages 163-163
    2. Edward Araujo Júnior, Gabriele Tonni, Waldo Sepulveda
      Pages 165-170
    3. Mario Lituania, Gabriele Tonni
      Pages 183-187
    4. Gabriele Tonni, Jurandir Piassi Passos, Mario Lituania
      Pages 189-193

About this book


This book describes how different diagnostic techniques may facilitate the prenatal identification of orofacial malformations. The role of standard two-dimensional ultrasound is documented and explained, but detailed attention is also paid to the use of three-dimensional (3D) ultrasound, including the novel 3D reslicing technique, and to the value of complementary magnetic resonance imaging. The malformations considered include cleft lip, cleft lip and palate, ocular malformations, abnormalities associated with fetal aneuploidy, and tumors. These conditions are depicted in numerous high-quality images accompanied by thorough and informative descriptions of imaging findings. The excellence of the illustrative material and the caliber of the authors, who are leading international experts in the field, ensure that Prenatal Diagnosis of Orofacial Malformations will be an invaluable tool for obstetricians and gynecologists.


2D sonography 3D sonography Fetal aneuploidy Fetal tumors Ocular malformations Cleft lip and palate Orofacial malformations Prenatal diagnosis Fetal anomalies

Editors and affiliations

  • Gabriele Tonni
    • 1
  • Waldo Sepulveda
    • 2
  • Amy E. Wong
    • 3
  1. 1.Department of Obstetrics and GynecologyPrenatal Diagnostic Service, Guastalla Civil Hospital AUSL Reggio EmiliaReggio EmiliaItaly
  2. 2.Maternal-Fetal Diagnostic CenterFetalmedSantiagoChile
  3. 3.Department of Maternal-Fetal Medicine Palo Alto Medical FoundationMountain ViewUSA

About the editors

Gabriele Tonni, PhD, MD, graduated Magna cum Laude in Obstetrics and Gynecology at the University of Parma. He is currently Consultant in Maternal-Fetal Medicine at Azienda Sanitaria Locale, Reggio Emilia, Italy. In the early 1990s, he has carried out research in the field of perinatal medicine investigating the role of intrapartum asphyxia and perinatal brain damage under the guidance of Professor James A. Low at the Queen’s University in Kingston, Canada. After gaining work experience in the United Kingdom, where he was granted RCOG certification in minimally invasive gynecologic surgery, he started to practice prenatal ultrasound diagnosis. He was trained in fetal invasive procedure at Nottingham City Hospital, under the guidance of Professor David T. Liu. He holds the Diploma in Fetal Medicine, the highest degree awarded by the Fetal Medicine Foundation, London. He has produced a PhD thesis on first trimester screening for fetal aneuploidy at University “La Sapienza” in Rome in 2000, the first publication on this clinical issue in Italy. Dr. Gabriele Tonni has been devoted to develop applications for 3D ultrasound and fetal MRI in the antenatal detection of congenital anomalies, particularly to the study of fetal palate and orofacial malformations, in which he gained worldwide expertise. He has developed outstanding international collaborations and is currently involved in the applications of 3D virtual physical models of fetal abnormalities using 3D ultrasound volume and fetal MRI scan data. He has contributed to more than 100 publications in peer-reviewed journals and serves as reviewer to more than 40 international journals. He has been invited to attend many national and international congresses where he acted as chairman or lecturer and has attended the Fetal Medicine Center, Hospital Clinic, Barcelona University

Amy Wong is a Maternal-Fetal Medicine physician practicing at Palo Alto Medical Foundation in California, USA. She received her undergraduate degree at Princeton University, her medical degree at the University of California, San Francisco, and Obstetrics and Gynecology training at Stanford University. Her subspecialty training in maternal-fetal medicine was performed at Northwestern University, where she also received her Master of Public Degree. 

Bibliographic information

  • Book Title Prenatal Diagnosis of Orofacial Malformations
  • Editors Gabriele Tonni
    Waldo Sepulveda
    Amy E. Wong
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-32514-9
  • Softcover ISBN 978-3-319-81305-9
  • eBook ISBN 978-3-319-32516-3
  • Edition Number 1
  • Number of Pages XVII, 219
  • Number of Illustrations 39 b/w illustrations, 154 illustrations in colour
  • Topics Obstetrics/Perinatology/Midwifery
  • Buy this book on publisher's site
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