© 2016

Biophysics of Infection

  • Mark C. Leake

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 915)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Mark C. Leake
    Pages 1-3
  3. Adam J. M. Wollman, Aisha H. Syeda, Peter McGlynn, Mark C. Leake
    Pages 5-16
  4. K. L. Thornton, R. C. Findlay, P. B. Walrad, L. G. Wilson
    Pages 17-32
  5. Alys K. Jepson, Jana Schwarz-Linek, Lloyd Ryan, Maxim G. Ryadnov, Wilson C. K. Poon
    Pages 33-48
  6. Jane E. King, Ian S. Roberts
    Pages 129-156
  7. Cibran Perez-Gonzalez, Jonathan P. Grondin, Daniel A. Lafontaine, J. Carlos Penedo
    Pages 157-191
  8. Dmitri O. Pushkin, Martin A. Bees
    Pages 193-205
  9. Nan Zhang, Goran Jovanovic, Christopher McDonald, Oscar Ces, Xiaodong Zhang, Martin Buck
    Pages 207-230
  10. Sebastian Aguayo, Laurent Bozec
    Pages 245-260
  11. Robert D. Barker, Laura E. McKinley, Simon Titmuss
    Pages 261-282
  12. Stefania Spanò
    Pages 283-294
  13. L. Albergante, D. Liu, S. Palmer, T. J. Newman
    Pages 295-305
  14. Zhaokun Zhou, Mark C. Leake
    Pages 307-327

About this book


This book describes modern biophysical techniques that enable us to understand and examine dynamic processes of infection at the molecular level. Cutting-edge research articles, laboratory protocols, case studies and up-to-date reviews cover topics such as single-molecule observation of DNA replication repair pathways in E. coli; evolution of drug resistance in bacteria; restriction enzymes as barriers to horizontal gene transfer in Staphylococcus aureus; infectious and bacterial pathogen biofilms; killing infectious pathogens through DNA damage; bacterial surfaces in host-pathogen interactions; bacterial gene regulation by riboswitches; transcription regulation in enterobacterial pathogens; the bacterial flagellar motor; initial surface colonization by bacteria; Salmonella Typhi host restrictions; as well as monitoring proton motive force in bacteria; microbial pathogens using digital holography; mathematical modelling of microbial pathogen motility; neutron reflectivity in studying bacterial membranes; force spectroscopy in studying infection and 4D multi-photon imaging to investigate immune responses. The focus is on the development and application of complex techniques and protocols at the interface of life sciences and physics, which increase the physiological relevance of biophysical investigations.


Antimicrobial resistance Bacterial motility Biofilms Biophysical imaging Disease modelling Immunology

Editors and affiliations

  • Mark C. Leake
    • 1
  1. 1.Biological Physical Sciences InstituteUniversity of YorkYorkUnited Kingdom

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