© 2016

Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis, and Pharmacotherapy

  • Carlos A. Zarate Jr.
  • Husseini K. Manji

Part of the Milestones in Drug Therapy book series (MDT)

Table of contents

  1. Front Matter
    Pages i-x
  2. Bipolar Depression: Clinical Phenotype and Course of Illness

    1. Front Matter
      Pages 1-1
    2. Philip B. Mitchell
      Pages 3-16
    3. Rodrigo Escalona, Mauricio Tohen
      Pages 33-51
    4. Zoltán Rihmer, Péter Döme
      Pages 53-69
  3. Bipolar Depression: Neurobiology

    1. Front Matter
      Pages 71-71
    2. Liping Hou, Francis J. McMahon
      Pages 73-92
    3. Araba F. Chintoh, L. Trevor Young
      Pages 93-114
    4. Jonathan Savitz, Harvey M. Morris, Wayne C. Drevets
      Pages 137-181
  4. Acute and Long-term Treatment of Bipolar Depression

    1. Front Matter
      Pages 183-183
    2. Rodrigo Machado-Vieira, Ioline D. Henter, Husseini K. Manji, Carlos A. Zarate Jr.
      Pages 259-285
  5. Treatment of Bipolar Disorder in Special Populations

    1. Front Matter
      Pages 287-287
    2. John L. Beyer, K. Ranga R. Krishnan
      Pages 289-313
    3. Dana Baker Kaplin, Robert L. Findling
      Pages 315-329

About this book


This book brings together mental health professionals and researchers to offer the most up-to-date information on the diagnosis, treatment, and research surrounding bipolar depression. Its individual chapters provide valuable diagnostic information, allowing clinicians to distinguish between the various mood disorders. Further, they: review the course, outcome, and genetics of this highly heritable condition; offer a thorough overview of the neurobiology of the disorder, including what is known from neuroimaging work; delineate the treatment of bipolar depression in special populations such as children and pregnant women; address suicide, focusing on the need for assessment during both acute and maintenance treatment with interventions appropriate to a patient’s symptoms and history; and cover acute and long-term treatment strategies for bipolar depression, including both traditional and novel therapeutics for the disorder, as well as non-pharmacological treatments.
This second edition reflects significant advances, including an improved understanding of the altered neurobiology of patients suffering from bipolar depression, new information on pathophysiology and genetic findings drawn from diverse studies, and a discussion of the significant strides made towards improved treatment with already available and novel agents.


Antidepressants Mental health Melancholia Mania Mood stabilizer Suicide risk factors and prevention Major depressive episode Bipolar disorders

Editors and affiliations

  • Carlos A. Zarate Jr.
    • 1
  • Husseini K. Manji
    • 2
  1. 1.Experimental Therapeutics and Pathophysiology BranchNational Institute of Mental Health, National Institutes of HealthBethesdaUSA
  2. 2.Janssen Pharmaceuticals of Johnson and Johnson, Janssen Research and DevelopmentTitusvilleUSA

About the editors


Bibliographic information

  • Book Title Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis, and Pharmacotherapy
  • Editors Carlos A. Zarate Jr.
    Husseini K. Manji
  • Series Title Milestones in Drug Therapy
  • Series Abbreviated Title Milestones in Drug Therapy
  • DOI
  • Copyright Information Springer International Publishing Switzerland (outside the USA) 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-31687-1
  • Softcover ISBN 978-3-319-81096-6
  • eBook ISBN 978-3-319-31689-5
  • Series ISSN 2296-6056
  • Series E-ISSN 2296-6064
  • Edition Number 2
  • Number of Pages X, 371
  • Number of Illustrations 2 b/w illustrations, 10 illustrations in colour
  • Topics Pharmacology/Toxicology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Pharmacology & Toxicology
Consumer Packaged Goods