Alternating Electric Fields Therapy in Oncology

A Practical Guide to Clinical Applications of Tumor Treating Fields

  • Eric T.¬†Wong

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Nidhi Gera, Kenneth D. Swanson
    Pages 1-14
  3. Edwin Lok, Erno Sajo
    Pages 15-27
  4. Cornelia Wenger, Pedro C. Miranda
    Pages 29-39
  5. Edwin Lok, Eric T. Wong, Erno Sajo
    Pages 41-54
  6. Josef Vymazal, Aaron M. Rulseh, Eric T. Wong
    Pages 55-65
  7. Jacob Ruzevick, Eric T. Wong, Maciej M. Mrugala
    Pages 79-92
  8. Mario E. Lacouture, John DeNigris, Andrew A. Kanner
    Pages 103-116
  9. Eric T. Wong, Minesh P. Mehta, Andrew A. Kanner, Manmeet S. Ahluwalia
    Pages 117-126
  10. Back Matter
    Pages 127-129

About this book

Introduction

This concise text provides a complete overview of alternating electric fields therapy -- also known as tumor treating fields -- for glioblastoma and other types of solid tumor malignancies. Readers are given a fundamental understanding of this novel anti-cancer treatment modality by learning from clinical trial data as well as the physical and cell biology effects on tumor cells when alternating electric fields are applied both in vitro and in vivo.

Chapters illustrate the physics behind electric field propagation in space and other media. This is followed by a review of our current understanding of the electric field effects on dividing cells - including the disruption of cytokinesis, proper chromosome segregation and activation on the cell surface chaperons that induce immunogenic cell death. Data from phase III trials for the treatment of recurrent and newly diagnosed glioblastomas are included, as well as some of the ancillary post hoc analyses that were performed by various investigators. The remainder of the chapter covers other solid tumor malignancies, including non-small cell lung cancer, pancreatic cancer and ovarian cancer, as this treatment modality is being applied to systemic malignancies.

Alternating Electric Fields Therapy in Oncology offers oncologists, neurologists, radiation oncologists, biomedical engineers, cell biologists and mitosis researchers the fundamentals needed for clinical practice.

Keywords

alternating electric fields therapy anti-cancer treatment glioblastomas neuro-oncology non-small cell lung cancer ovarian cancer pancreatic cancer

Editors and affiliations

  • Eric T.¬†Wong
    • 1
  1. 1.Division of Neuro-Oncology Department of NeurologyBeth Israel Deaconess Medical CenterBostonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-30576-9
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-30574-5
  • Online ISBN 978-3-319-30576-9
  • About this book
Industry Sectors
Biotechnology
Pharma