Histophilus somni

Biology, Molecular Basis of Pathogenesis, and Host Immunity

  • Thomas J. Inzana

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 396)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Øystein Angen
    Pages 1-14
  3. D. O’Toole, K. S. Sondgeroth
    Pages 15-48
  4. Shivakumara Siddaramappa
    Pages 49-70
  5. Erica Behling-Kelly, Jose Rivera-Rivas, Charles J. Czuprynski
    Pages 71-87
  6. Lynette B. Corbeil
    Pages 89-107
  7. Lynette B. Corbeil
    Pages 109-129
  8. Briana Petruzzi, Thomas J. Inzana
    Pages 149-160

About this book


This volume reviews the current understanding of the taxonomy, disease syndromes, genetics, biology, and pathogenic factors of Histophilus somni, as well as the host immune response to this pathogen. H. somni is one of the most important bacterial pathogens in cattle and other ruminants, and its virulence factors are highly conserved with Haemophilus influenzae and other members of the PasteurellaceaeH. somni has been recognized as a major cause of thrombotic meningoencephalitis, respiratory disease syndromes, myocarditis, reproductive disease syndromes, polyarthritis, mastitis, ocular disease, and septicemia. The only known habitats of H. somni are the mucosal surfaces of ruminants, making this bacterium an opportunistic pathogen. Although it is capable of causing inflammation at systemic sites and is toxic to epithelial and phagocytic cells, the bacterium’s wide array of virulence factors act primarily as a defense against, or to escape recognition from, host innate and adaptive immunity.


Pasteurellaceae Bacterial pathogen Biofilm formation in host colonization Feedlot cattle diseases Host endothelial cells Host specific pathogen H. somni Histophilosis Exopolysaccharide production

Editors and affiliations

  • Thomas J. Inzana
    • 1
  1. 1.Virginia-Maryland Reg. College of VVirginia Tech-Carilion School of MeBlacksburgUSA

Bibliographic information

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