© 2016

Radiobiology of Glioblastoma

Recent Advances and Related Pathobiology

  • Luigi Pirtoli
  • Giovanni Luca Gravina
  • Antonio Giordano
  • Provides the most recent and relevant advances in molecular radiobiology of glioblastoma, and the related possible changes in the clinical setting

  • Written by experts in the field

  • Bridges the gap of knowledge and methodology in approaching RB of GB between basic researchers and clinical investigators


Part of the Current Clinical Pathology book series (CCPATH)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Luigi Pirtoli, Giovanni Luca Gravina, Antonio Giordano
    Pages 1-11
  3. From Bedside to Bench: Radiobiological Topics Arising from Clinical Studies

    1. Front Matter
      Pages 13-13
    2. Michela Buglione, Luca Triggiani, Paolo Borghetti, Sara Pedretti, Nadia Pasinetti, Stefano Maria Magrini
      Pages 15-27
    3. Silvia Scoccianti, Riccardo Santoni, Beatrice Detti, Gianluca Ingrosso, Daniela Greto, Giulio Francolini
      Pages 29-40
    4. Silvia Chiesa, Mario Balducci, Milena Ferro, Anna Rita Alitto, Vincenzo Valentini
      Pages 41-62
    5. Walter Tinganelli, Marco Durante, Alexander Helm
      Pages 63-85
    6. Piernicola Pedicini, Lidia Strigari, Luigi Spiazzi, Alba Fiorentino, Paolo Tini, Luigi Pirtoli
      Pages 87-100
    7. Paolo Tini, Clelia Miracco, Marzia Toscano, Silvia Palumbo, Sergio Comincini, Giovanni Luca Gravina et al.
      Pages 101-120
    8. Francesca De Felice, Vincenzo Tombolini, Michela Buglione, Daniela Musio, Luca Triggiani, Stefano Maria Magrini
      Pages 121-135
  4. Preclinical Research

    1. Front Matter
      Pages 139-139
    2. Monica Mangoni, Mariangela Sottili, Chiara Gerini, Lorenzo Livi
      Pages 139-153
    3. Benjamin Cooper, Ralph Vatner, Encouse Golden, Joshua Silverman, Silvia Formenti
      Pages 155-175
    4. A. Cimini, A. Fidoamore, M. d’Angelo, A. Antonosante, L. Cristiano, E. Benedetti et al.
      Pages 177-187
    5. Mariangela Sottili, Chiara Gerini, Isacco Desideri, Mauro Loi, Lorenzo Livi, Monica Mangoni
      Pages 189-207
    6. Marzia Toscano, Silvia Palumbo, Paolo Tini, Clelia Miracco, Giovanni Luca Gravina, Sergio Comincini
      Pages 209-224
    7. Silvia Palumbo, G. Belmonte, Paolo Tini, Marzia Toscano, Clelia Miracco, Sergio Comincini
      Pages 225-237
    8. Elisa Panzarini, Luciana Dini
      Pages 239-252
  5. From Bench to Bedside: Translational Perspectives

    1. Front Matter
      Pages 253-253
    2. Anita Tandle, Uma Shankavaram, Cody Schlaff, Kevin Camphausen, Andra Krauze
      Pages 255-274

About this book


This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models. 

Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators. 


Particle Radiation Therapy Radiobiological Parameters Tumor Initiation Tumor Microenvironment Gene Therapy

Editors and affiliations

  • Luigi Pirtoli
    • 1
  • Giovanni Luca Gravina
    • 2
  • Antonio Giordano
    • 3
  1. 1.University of SienaSec. of Radiation Oncology,Dept. of Med.SienaItaly
  2. 2.Dept. of Applied Clinical & Biotech Sci.University of L’AquilaL’AquilaItaly
  3. 3.Department of BiologyTemple UniversityPhiladelphiaUSA

About the editors

Dr. Luigi Pirtoli
Radiation Oncology Unit
Department of Medicine, Surgery and Neurosciences
University of Siena
Siena, Italy

Dr. Giovanni Luca Gravina
Department of Biology and Biotechnology
University of Pavia
Rome, Italy

Antonio Giordano
Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology
Temple University
Philadelphia, PA, USA
Department of Medicine, Surgery & Neurosciences
University of Siena
Siena, Italy

Bibliographic information

  • Book Title Radiobiology of Glioblastoma
  • Book Subtitle Recent Advances and Related Pathobiology
  • Editors Luigi Pirtoli
    Giovanni Luca Gravina
    Antonio Giordano
  • Series Title Current Clinical Pathology
  • Series Abbreviated Title Current Clinical Pathology
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Humana Press, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-28303-6
  • Softcover ISBN 978-3-319-80321-0
  • eBook ISBN 978-3-319-28305-0
  • Series ISSN 2197-781X
  • Series E-ISSN 2197-7828
  • Edition Number 1
  • Number of Pages XX, 305
  • Number of Illustrations 10 b/w illustrations, 39 illustrations in colour
  • Topics Pathology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals


“This is a very detailed monograph on the roles of radiation, immunotherapy, genetic, epigenetic, and chemotherapy in the treatment of Glioblastoma. Biomarkers and molecular mechanisms of GBMs are discussed. … I highly recommend this book to oncologists, neurosurgeons, neurologists, and researchers involved in this perplexing baffling tumor.” (Joseph Grenier,, May, 2018)