Growth Hormone Deficiency

Physiology and Clinical Management

  • Laurie E. Cohen

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Mechanisms of Human Growth Hormone Secretion and Action

    1. Front Matter
      Pages 5-5
    2. Philippe Backeljauw, Vivian Hwa
      Pages 7-20
    3. Diane E. J. Stafford
      Pages 21-27
    4. Angela M. Leung, Gregory A. Brent
      Pages 29-46
    5. Takara L. Stanley
      Pages 63-77
  3. Diagnosis of Human Growth Hormone Deficiency

    1. Front Matter
      Pages 93-93
    2. Natascia Di Iorgi, Giovanni Morana, Flavia Napoli, Andrea Rossi, Mohamad Maghnie
      Pages 123-146
  4. Etiologies of Human Growth Hormone Deficiency

    1. Front Matter
      Pages 147-147
    2. Jan M. Wit, Monique Losekoot, Gerhard Baumann
      Pages 149-175
    3. Frédéric Castinetti, Thierry Brue
      Pages 177-194
    4. Wassim Chemaitilly
      Pages 195-204
    5. Erick Richmond, Alan D. Rogol
      Pages 205-211
  5. Back Matter
    Pages 223-228

About this book


Providing the most current information on the function of human growth hormone (GH) and the consequences of its deficiency, this practical yet comprehensive text is divided into three sections. Part one describes the mechanisms of GH secretion and action, including the physiology of GH and its regulation by sex steroids and thyroid hormones, the effects of both under nutrition and obesity on GH secretion, and the metabolic effects of human recombinant GH therapy. The second section covers diagnostic strategies and tests for GH deficiency in both children and adults, including MRI of the pituitary. The final section describes the different etiologies of GH deficiency, from molecular mechanisms and gene abnormalities to cranial radiation and traumatic brain injury, along with syndromes related to this deficiency. Presenting underlying mechanisms and pathologies, as well as diagnostic methods, Growth Hormone Deficiency will provide the most up-to-date essential information and evidence on this condition for the clinical endocrinologist.


Gene abnormalities HGH Hormone replacement therapy Human growth hormone Pituitary development Somatotropin

Editors and affiliations

  • Laurie E. Cohen
    • 1
  1. 1.Harvard Medical School Boston Children's HospitalBostonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-28036-3
  • Online ISBN 978-3-319-28038-7
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology