Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents

  • Michael W. Jann
  • Scott R.  Penzak
  • Lawrence J. Cohen

Table of contents

  1. Front Matter
    Pages i-xiv
  2. General Pharmacokinetic and Pharmacodynamic Principles of Psychopharmacological Agents

    1. Front Matter
      Pages 1-1
    2. Mark S. Luer, Scott R. Penzak
      Pages 3-27
    3. Carlos H. Rojas-Fernandez
      Pages 29-48
    4. Jonathon A. Nye, Leonard Howell
      Pages 49-70
    5. Ayyappa Chaturvedula
      Pages 71-90
    6. Scott R. Penzak
      Pages 91-119
    7. Kristen M. Wiese, Stephanie A. Flowers, Vicki L. Ellingrod
      Pages 121-135
  3. Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Drug Classes

    1. Front Matter
      Pages 137-137
    2. Michael W. Jann, W. Klugh Kennedy
      Pages 139-175
    3. Edoardo Spina, Domenico Italiano
      Pages 177-203
    4. Patrick R. Finley, Jennifer Le, Kelly C. Lee
      Pages 205-245
    5. Sally K. Guthrie, Christian Teter
      Pages 267-301
    6. Chad M. VanDenBerg, Michael W. Jann
      Pages 329-349
    7. Michael W. Jann
      Pages 351-372
  4. Clinically Significant Drug Interactions with Psychopharmacological Agents

    1. Front Matter
      Pages 395-395
    2. Mong-Liang Lu, Hsien-Yuan Lane
      Pages 397-421
    3. David Taylor, Kalliopi Vallianatou
      Pages 423-449
    4. Jose Valdes, Douglas L. Boggs, Angela A. Boggs, Jose A. Rey
      Pages 471-495
    5. Tony K. L. Kiang, Mary H. H. Ensom
      Pages 497-534
    6. Janet K. Coller, Daniel T. Barratt, Andrew A. Somogyi
      Pages 565-577

About this book


This book is a comprehensive resource on psychotropic medications, detailing the latest methods for defining their characteristics, their use in different patient populations, and drug-drug interactions; an important collection of information forclinicians, students, researchers, and members of the pharmaceutical industry alike.

The first section provides the foundational principles of these drugs. Mathematical modeling of parameters that affect their entryto,and exit from, the central nervous system (CNS) compartment are presented on an individual basis and then applied to target populations with specific disease states. Methods and characteristics that inform the transfer of these drugs from the laboratory bench to use in patient care are discussed, including imaging techniques, genetics and physiological barriers, such as the blood-brain barrier. The second section describes the characteristics of specific agents,nominally arranged intodifferent therapeutic categories and with reference crossover use in different disease states. The pharmacologic characteristics of different drug formulations are explored in the context of their ability to improve patient adherence. The third section focuses on drug-drug interactions.Psychotropic medications from different categories are frequently prescribed together,or alongside medications used to treat comorbid conditions, and the information provided is directly relevant to the clinic, as a result.

The clinical application of pharmacokinetics and pharmacodynamics of CNS agents has made significant progress over the past 50 years and new information is reported by numerous publications in psychiatry, neurology, and pharmacology.Our understanding of the interrelationship between these medications, receptors, drug transporters, as well as techniques for measurement and monitoring their interactions,isfrequently updated. However, with information presented on a host of different platforms, and in different formats, obtaining the full picture can be difficult. This title aims to collate this information into a single source that can be easily interpreted and applied towards patient care by the clinical practitioner, and act as a reference for all others who have an interest in psychopharmacological agents.


Acetylaldehyde Hydrogenase Atypical Candidate Gene Cell Membrane Central Nervous System CYP2C19 Enzyme Emax Model Grapefruit Juice Immediate-Release Formulation Immunosuppressants Inhibitor Kappa Opiate Receptor Modeling Analysis Muscle Relaxant N-Methyl-D-Aspartate (NMDA) Receptor Non-Steroid Anti-inflammatory Drugs (NSAIDs) Prophylaxis Protein Binding Interactions Radiotracer Receptor Systems

Editors and affiliations

  • Michael W. Jann
    • 1
  • Scott R.  Penzak
    • 2
  • Lawrence J. Cohen
    • 3
  1. 1.Univ. North Texas Sys, Col PharmacyDepartment of PharmacotherapyFORT WORTHUSA
  2. 2.Department of PharmacotherapyUniv. North Texas Sys, Col PharmFORT WORTHUSA
  3. 3.Department of PharmacotherapyUniv. North Texas Sys, Col Pharm.FORT WORTHUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Adis, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-27881-0
  • Online ISBN 978-3-319-27883-4
  • Buy this book on publisher's site
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