Targeting Oral Cancer

  • Andrew M. Fribley

Table of contents

  1. Front Matter
    Pages i-x
  2. The Dynamic Epidemiology of Head and Neck Cancers and Current Treatment Modalities

    1. Front Matter
      Pages 1-1
    2. Michael Z. Chen, Robert H. Mathog, Andrew M. Fribley, George H. Yoo
      Pages 37-52
    3. Daniela M. Burchhardt, Ammar Sukari
      Pages 53-68
  3. HNSCC: Molecular Progression, Biomarkers and Stem Cells

    1. Front Matter
      Pages 69-69
    2. Insoon Chang, Aasia O. Rehman, Cun-Yu Wang
      Pages 71-99
    3. Hong S. Kim, April Adams, Jacques E. Nör
      Pages 101-113
    4. Martina Raudenska, Jaromir Gumulec, Andrew M. Fribley, Michal Masarik
      Pages 115-160
  4. Current Trends in Head and Neck Cancer Treatment and Novel Therapeutic Approaches

    1. Front Matter
      Pages 161-161
    2. Zipei Feng, Carlo B. Bifulco, Rom Leidner, R. Bryan Bell, Bernard A. Fox
      Pages 211-224
    3. Danielle M. Garshott, Shelby A. Bechler, Daniela M. Burchhardt, Priyanka Shah O’Brien, George H. Yoo, Daniel J. Chiego Jr. et al.
      Pages 225-261
    4. Rohith Jesudas, Qinghua Zeng, Danielle M. Garshott, Nicholas Yoo, Andrew M. Fribley, Jordan A. Shavit et al.
      Pages 263-281
    5. Peter F. Svider, Blake M. Warner, Scott J. Schwartz, Danielle M. Garshott, James D. Weinstein, Andrew M. Fribley
      Pages 283-299
  5. Back Matter
    Pages 301-302

About this book


This book provides research-oriented care providers with up-to-date information on the oral cancer patient population, the ways in which we are treating them, and the scientific approaches being pursued in order to improve survival and reduce treatment-related morbidity. The text is organized into three sections covering epidemiology and management, cancer development and biomarkers, and breaking developments and novel approaches for drug discovery. The first section includes discussion of the emerging role of human papillomavirus in oral cancer and explains the surgical, chemotherapy, and radiation approaches to treatment. Aspects such as molecular progression and signaling, the role of cancer stem cells in tumor development, and the value of various biomarkers are then examined. The final section is devoted to the latest advances and covers, among other topics, current clinical trials, emerging drug targets, and targeting of the unfolded protein response and of mediators of coagulation.

Recent decades have witnessed a significant increase in the number of deaths worldwide from cancers of the oral cavity, pharynx, and oropharynx. Targeting Oral Cancer will be an excellent resource for practitioners and researchers and will hopefully assist in the urgent quest to improve screening and prevention, diagnosis, and treatment approaches.


Biomarkers Cancer Stem Cells Chemotherapy Human Papillomavirus Surgical Management Molecular Signaling UPR

Editors and affiliations

  • Andrew M. Fribley
    • 1
  1. 1.School of MedicineWayne State UniversityDETROITUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-27645-8
  • Online ISBN 978-3-319-27647-2
  • Buy this book on publisher's site
Industry Sectors