The state of the art in Biopharmaceutics, Pharmacokinetics, and
Pharmacodynamics Modeling is presented in this new second edition book.
It shows how advanced physical and mathematical methods can expand
classical models in order to cover heterogeneous drug-biological
processes and therapeutic effects in the body.
The book is divided
into four parts; the first deals with the fundamental principles of
fractals, diffusion and nonlinear dynamics; the second with drug
dissolution, release, and absorption; the third with epirical,
compartmental, and stochastic pharmacokinetic models, with two new
chapters, one on fractional pharmacokinetics and one on bioequivalence;
and the fourth mainly with classical and nonclassical aspects of
pharmacodynamics. The classical models that have relevance and
application to these sciences are also considered throughout. This
second edition has new information on reaction limited models of
dissolution, non binary biopharmaceutic classification system, time
varying models, and interface models. Many examples are used to
illustrate the intrinsic complexity of drug administration related
phenomena in the human, justifying the use of advanced modeling methods.
book will appeal to graduate students and researchers in pharmacology,
pharmaceutical sciences, bioengineering, and physiology.
Reviews of the first edition:
book presents a novel modelling approach to biopharmaceutics,
pharmacokinetics and pharmacodynamic phenomena. This state-of-the-art
volume will be helpful to students and researchers in pharmacology,
bioengineering, and physiology. This book is a must for pharmaceutical
researchers to keep up with recent developments in this field." (P. R.
Parthasarathy, Zentralblatt MATH, Vol. 1103 (5), 2007)
authors are the unique (or sole) contributors in this area that are
working on these questions and bring a special expertise to the field
that is now being recognized as essential to understanding biological
system and kinetic/dynamic characteristics in drug development...This
text is an essential primer for those who would envision the
incorporation of heterogeneous approaches to systems where homogeneous
approaches are not sufficient to describe the system." (Robert R. Bies,
Journal of Clinical Pharmacology, Vol. 46, 2006)