The Mathematics and Biology of the Biodistribution of Radiopharmaceuticals - A Clinical Perspective

This book explores the mathematics and biology of the biodistribution of radiopharmaceuticals following their introduction into the body, but does so primarily from a clinical perspective – from the point of view of image interpretation and any associated image-derived quantification. All of the equations included in the book relate directly to the biodistribution of radiopharmaceuticals and are clinically useful, either conceptually or because of their value in quantifying a biological parameter, e.g., renal clearance. In particular, the more complex equations are not meant to be solved but instead are intended to provide a conceptual basis for the analysis of clinical images, especially those that are unusual and/or difficult to interpret. The efficacy of every diagnostic and therapeutic nuclear medicine procedure is critically dependent on the biodistribution of the radiopharmaceutical in question over time. This book will enable the reader to gain a sound understanding of the relevant mathematics and biology, and the clinical orientation ensures that it will be of value in enhancing clinical practice.

“This is a concise and comprehensive book to provide perhaps a different perspective in explaining the images produced in diagnostic nuclear medicine procedures. … the author effectively incorporates figures, tables, images, and diagrams to further drive the point home.” (Dao Le, Journal of Nuclear Medicine JNM, Vol. 58(4), April, 2017)

“The author does a good job with the addition of meticulous illustrations and explanations to guide the readers to understand the equations. … When the equations are presented, the author breaks down each component of the equation and allows for a biologic description for each mathematical factor. … author effectively incorporates figures, tables, images and diagrams to further drive the point home. … For those who are interested in exploring other approaches to nuclear medicine, the book … is recommended.” (Dao M. Le, Journal of Nuclear Medicine, February, 2017)

“The concept of the volume is to explain the mathematical rules,which subtend the bio-distribution of radiopharmaceuticals by giving only the most valuable information that can be applied in clinical setting. This particular approach makes the book extremely useful … . The book is enriched … by figures of clinical cases, by many tables, graphs and cartoons ... . an interesting, detailed and cultured publication … . this volume cannot be absent in all the libraries of diagnostic imaging departments … .” (Teresa Mannarino and Luigi Mansi, European Journal of Nuclear Medicine and Molecular Imaging, November, 2016)

William C. Klingensmith III, M.D. attended Cornell University in Ithaca, NY and then Cornell University’s College of Medicine in New York City. He completed an internship in medicine at the University of Oregon School of Medicine in Portland, OR, a residency in radiology at the University of Colorado School of Medicine in Denver, CO, and a fellowship in nuclear medicine at the Johns Hopkins University School of Medicine in Baltimore, MD. Then he returned to the University of Colorado School of Medicine as the head of nuclear medicine for seven years. He then joined Radiology Imaging Associates, a large academically oriented private practice radiology group in Denver. After 25 years in private practice he returned to the University of Colorado School of Medicine to again head nuclear medicine.

Dr. Klingensmith has had an interest in the mathematics and biology of radiopharmaceutical localization throughout his career. During his nuclear medicine fellowship he determined the information content of first circulation time-activity curves. More recently he developed the clinically oriented equation for clearance of a radiopharmaceutical from blood into tissue, and the general algorithm for determining whether a physiologic measurement needs to be normalized for body size.