© 2017

The Breathless Heart

Apneas in Heart Failure

  • Michele Emdin
  • Alberto Giannoni
  • Claudio Passino

Table of contents

  1. Front Matter
    Pages i-viii
  2. Michele Emdin, Alberto Aimo
    Pages 1-9
  3. Claudio Passino, Elisabetta Cacace, Daniele Caratozzolo, Federico Rossari, Luigi Francesco Saccaro
    Pages 11-33
  4. Alberto Giannoni, Chiara Borrelli, Valentina Raglianti
    Pages 35-90
  5. Alberto Giannoni, Maria Sole Morelli, Darrel Francis
    Pages 91-123
  6. Alberto Giannoni, Alberto Aimo, Francesca Bramanti, Massimo F. Piepoli
    Pages 125-145
  7. Jens Spießhöfer, Olaf Oldenburg
    Pages 147-168
  8. Maria Teresa La Rovere, Roberto Maestri, Gian Domenico Pinna
    Pages 169-181
  9. Gianluca Mirizzi, Alberto Giannoni, Claudio Passino, Michele Emdin
    Pages 203-217
  10. Roberta Poletti, Alberto Aimo, Vincenzo Castiglione, Alessandro Di Gangi, Giovanni Iudice, Mauro Micalizzi et al.
    Pages 219-234
  11. Margherita Padeletti, Fabrizio Bandini, Edoardo Gronda, Luigi Padeletti
    Pages 235-245
  12. Claudio Passino, Alberto Giannoni, Alberto Aimo, Gianluca Mirizzi, Michele Emdin
    Pages 247-270
  13. Maria Rosa Costanzo
    Pages 271-284
  14. Michele Emdin, Alberto Giannoni, Claudio Passino
    Pages 285-287

About this book


This book systematically focuses on central sleep apneas, analyzing their relationship especially with heart failure and discussing recent research results and emerging treatment strategies based on feedback modulation. The opening chapters present historical background information on Cheyne-Stokes respiration (CSR), clarify terminology, and explain the mechanics and chemistry of respiration. Following a description of the physiology of respiration, the pathophysiology underlying central apneas in different disorders and particularly in heart failure is discussed. The similarities and differences of obstructive and central apneas are then considered. The book looks beyond the concept of sleep apnea to daytime CSR and periodic breathing during effort and contrasts the opposing views of CSR as a compensatory phenomenon or as detrimental to the failing heart. The diagnostic tools currently in use for the detection of CSR are thoroughly reviewed, with guidance on interpretation of findings. The book concludes by describing the various forms of treatment that are available for CSR and by explaining how to select patients for treatment.


Apneas Baroreceptors Chemoreceptors Chemoreflex Cheyne-Stokes respiration Feedback modulation Heart failure Periodic breathing Treatment for apnea

Editors and affiliations

  • Michele Emdin
    • 1
  • Alberto Giannoni
    • 2
  • Claudio Passino
    • 3
  1. 1.Fondazione Toscana Gabriele MonasterioPisaItaly
  2. 2.Fondazione Toscana Gabriele MonasterioPisaItaly
  3. 3.Fondazione Toscana Gabriele MonasterioPisaItaly

About the editors

Michele Emdin got his degree in 1983 and specialized in Cardiovascular Diseases at the Universities of Pisa and Milano, Italy. He started working at the CNR Foundation – Gabriele Monasterio in Pisa, Italy, right in 1983, within the Sant’Anna Hospital in Pisa. He worked as visiting assistant professor in Sao Paulo, Brazil, Boston, USA, and London, UK. Beside his important teaching activity started back in 1999, the research avenues he is pursuing are: serum GGT as cardiovascular risk factor, heart failure, ischemic cardiomyopathy, nervous and endocrine control of cardiovascular system. He is author of more than 190 papers and published a book with Springer already on natriuretic peptides.

Alberto Giannoni works as a cardiologist and researcher at the Fondazione Toscana Gabriele Monasterio in Pisa, Italy. He attended his PhD on cardiorespiratory interactions at the Scuola Superiore Sant’Anna, Pisa, Italy and at the Imperial College, London, UK. His main research interest focus on Cheyne-Stokes respiration and feed-back systems, chemoreflex, baroreflex and ergoreflex, in heart failure.

Claudio Passino is Assistant Professor of Cardiovascular Medicine at the Scuola Superiore Sant’Anna in Pisa. He specialized in cardiology and sports medicine. His main research interests focus on neuroendocrine regulation of the cardiovascular system, high altitude cardiac adaptation, evaluation of new risk factors in coronary artery disease.

Bibliographic information

  • Book Title The Breathless Heart
  • Book Subtitle Apneas in Heart Failure
  • Editors Michele Emdin
    Alberto Giannoni
    Claudio Passino
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2017
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-319-26352-6
  • Softcover ISBN 978-3-319-79939-1
  • eBook ISBN 978-3-319-26354-0
  • Edition Number 1
  • Number of Pages VIII, 287
  • Number of Illustrations 30 b/w illustrations, 20 illustrations in colour
  • Topics Cardiology
    Pneumology/Respiratory System
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology


“This is a thorough evaluation of apnea in heart failure, including physiology, pathology, clinical assessment, and treatment of various apneas in patients with cardiomyopathy. … This book is best suited for general cardiologists, advanced heart failure physicians, pulmonologists or sleep medicine physicians. However, it would be a great resource for any physicians, trainees, or medical students who are interested in cardiology to further refine their understanding of apneas in heart failure.” (George Irvin McLeod, Doody’s Book Reviews, April, 2017)