Cellular Ageing and Replicative Senescence

  • Suresh I.S. Rattan
  • Leonard Hayflick

Part of the Healthy Ageing and Longevity book series (HAL)

Table of contents

  1. Front Matter
    Pages i-viii
  2. History and Origins

    1. Front Matter
      Pages 1-1
    2. Suresh I. S. Rattan
      Pages 15-26
  3. Serial Passaging and Progressive Changes

  4. Ageing, Cancer and Senescence

    1. Front Matter
      Pages 143-143
    2. Renu Wadhwa, Zeenia Kaul, Sunil C. Kaul
      Pages 145-167
    3. Timothy Nacarelli, Claudio Torres, Christian Sell
      Pages 169-185
    4. Andreas Simm, Barbara Seliger, Lars-Oliver Klotz
      Pages 187-201
  5. Ageing Modulators

    1. Front Matter
      Pages 241-241
    2. Florence Debacq-Chainiaux, Randa Ben Ameur, Emilie Bauwens, Elise Dumortier, Marie Toutfaire, Olivier Toussaint
      Pages 243-262
    3. Elizabeth P. Crowe, S. Ferit Tuzer, Justin Cohen, Emre C. Yetkin, Luca D’Agostino, Christian Sell et al.
      Pages 263-286
    4. Joseph M. Dhahbi
      Pages 287-312
    5. Tobias Wijshake, Jan M. A. van Deursen
      Pages 313-343
  6. Recapitulation and Future Expectations

    1. Front Matter
      Pages 345-345
  7. Back Matter
    Pages 363-364

About this book


This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology.

Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.


Ageing Cancer Cell cycle regulation Longevity Stress

Editors and affiliations

  • Suresh I.S. Rattan
    • 1
  • Leonard Hayflick
    • 2
  1. 1.Dep of Molecular Biology and GeneticsAarhus UniversityAarhusDenmark
  2. 2.Department of Anatomy,School of MedicineUniversity of CaliforniaSan FranciscoUSA

Bibliographic information

Industry Sectors