Umbrella Reviews

Evidence Synthesis with Overviews of Reviews and Meta-Epidemiologic Studies

  • Giuseppe Biondi-Zoccai

Table of contents

  1. Front Matter
    Pages i-xii
  2. Umbrella Reviews in the Evidence Hierarchy

    1. Front Matter
      Pages 1-1
    2. Giuseppe Biondi-Zoccai
      Pages 3-10
    3. Colin Ng, Umberto Benedetto
      Pages 11-19
    4. Ana Ortega, Eduardo Lopez-Briz, María Dolores Fraga-Fuentes
      Pages 21-41
  3. Sound Design, Conduct, and Reporting

    1. Front Matter
      Pages 55-55
    2. Spyridon N. Papageorgiou, Giuseppe Biondi-Zoccai
      Pages 57-80
    3. Alison Booth
      Pages 81-93
    4. Su Golder, Kath Wright
      Pages 95-106
    5. Giuseppe Biondi-Zoccai, Giuseppe La Torre, Leonardo Roever, Fabrizio D’Ascenzo
      Pages 107-113
    6. William L. Baker, Meg Bennetts, Craig I. Coleman, Joseph C. Cappelleri
      Pages 115-135
    7. Tzu-Ting Chen, Yu-Kang Tu
      Pages 137-153
    8. Francisco José Vázquez Polo, Miguel A. Negrín, María Martel
      Pages 155-160
    9. Areti Angeliki Veroniki, Tania B. Huedo-Medina, Kostas N. Fountoulakis
      Pages 161-188
    10. Akira Onishi, Toshi A. Furukawa
      Pages 189-202
  4. Case Studies

    1. Front Matter
      Pages 203-203
    2. Clovis Mariano Faggion Jr, Utsana Tonmukayakul
      Pages 217-234
    3. David Andrew Osborn
      Pages 235-272
    4. Walter De Caro, Anna Rita Marucci, Loreto Lancia, Julita Sansoni
      Pages 273-303
    5. Maciej Płaszewski, Josette Bettany-Saltikov
      Pages 305-329
    6. Leandro Fórnias Machado de Rezende, Juan Pablo Rey-López, Olinda do Carmo Luiz, Jose Eluf-Neto
      Pages 331-341
    7. Clare Bambra, Marcia Gibson
      Pages 343-362
  5. Implementation and Further Research

    1. Front Matter
      Pages 363-363
    2. Fabrizio D’Ascenzo, Claudio Moretti, Christian Templin, Fiorenzo Gaita
      Pages 365-371
    3. Dawid Pieper, Lun Li, Roland Brian Büchter
      Pages 373-388
    4. Giuseppe Biondi-Zoccai
      Pages 389-391

About this book


​This book is an ideal guide to umbrella reviews, overviews of reviews, and meta-epidemiologic studies for evidence synthesis. Research is conducted at different levels: primary research consists of original studies while secondary research comprises qualitative reviews, systematic reviews, and meta-analyses. Recently, a novel further level of research has been introduced, based on the analysis and pooling of reviews and meta-analysis. This book is the first to focus solely on this new type of research design, which permits a comprehensive and powerful synthesis of scientific evidence in medicine as well as in many other fields in order to inform decision-making. All aspects are covered, including review design and registration, the searching, abstracting, appraisal, and synthesis of evidence, the appraisal of moderators and confounders, and state of the art reporting. Case studies in a range of medical specialties are then presented. The hands-on approach of the book, written by a multinational team of experts, will enable the reader to interpret and independently conduct umbrella reviews.


Comparative effectiveness research Evidence-based medicine Medical research Mixed treatment comparison Network meta-analysis Outcome research Evidence synthesis Meta-epidemiologic study Overview of reviews Umbrella review

Editors and affiliations

  • Giuseppe Biondi-Zoccai
    • 1
  1. 1.Dept of Medico-Surgical SciSapienza University of RomeLatinaItaly

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-25653-5
  • Online ISBN 978-3-319-25655-9
  • Buy this book on publisher's site
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