Stem Cells and Cardiac Regeneration

  • Rosalinda Madonna

Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Stem Cells Sources for Cardiac Regeneration. Basic Principles

    1. Front Matter
      Pages 1-1
    2. Rosalinda Madonna
      Pages 3-7
    3. Francesco Moccia, Federica Diofano, Paola Rebuzzini, Estella Zuccolo
      Pages 9-29
    4. Rosalinda Madonna, Peter Ferdinandy, Rainer Schulz
      Pages 31-43
  3. Critical Regulators of Stem Cell Differentiation for Myocardial Regeneration

    1. Front Matter
      Pages 55-55
    2. Pieterjan Dierickx, Bastiaan Du Pré, Dries A. M. Feyen, Niels Geijsen, Toon van Veen, Pieter A. Doevendans et al.
      Pages 57-78
    3. Martijn J. H. Doeleman, Dries A. M. Feyen, Christina F. de Veij Mestdagh, Joost P. G. Sluijter
      Pages 79-109
    4. Silvia Agostini, Marco Matteucci, Valentina Casieri, Gaia Papini, Vincenzo Lionetti
      Pages 111-122
    5. Felix B. Engel
      Pages 123-141
  4. Stem Cells and Stem Cell-related Strategies for Heart Regeneration

    1. Front Matter
      Pages 163-163
    2. Neil Davies, Kyle Goetsch, Malebogo Ngoepe, Thomas Franz, Sandrine Lecour
      Pages 165-190
  5. Back Matter
    Pages 197-205

About this book


This book provides an update of recent advances in the basic and clinical applications of cell-based therapies for myocardial repair and regeneration in ischemic heart disease (IHD) and heart failure (HF). The first sections of the book illuminate basic aspects of stem cells such as definitions, isolation criteria and characterization of embryonic and adult stem cells, as well as pluripotent stem cells and tissue specific progenitor and stem cells. In the following section, the text examines the role of critical regulators of stem cell differentiation in myocardial regeneration, that include circadian rhythyms, microRNAs, epigenetics, microvescicles, and exosomes. The text concludes with a review of the use of stem/progenitor cells in cardiac regeneration and discuss current controversies, unresolved issues, challenges, and future directions. Stem Cells and Cardiac Regeneration is addressed to a wide audience consisting of cardiologists, clinicians, and research scientists, who will learn new concepts in cardiovascular regeneration and repair with special focus on molecular mechanisms and therapeutic potential for cardiovascular regeneration. 


cardiomyocyte microRNAs myocardial regeneration pluripotent stem cells Epigenetics

Editors and affiliations

  • Rosalinda Madonna
    • 1
  1. 1.Institute of Cardiology, Department of Neurosciences and Imaging Laboratory of Experimental Cardiology"G. d'Annunzio" UniversityChieti ScaloItaly

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-25425-8
  • Online ISBN 978-3-319-25427-2
  • Series Print ISSN 2196-8985
  • Series Online ISSN 2196-8993
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals