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Patho-Epigenetics of Infectious Disease

  • Janos Minarovits
  • Hans Helmut Niller

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 879)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Janos Minarovits, Ferenc Banati, Kalman Szenthe, Hans Helmut Niller
    Pages 1-25
  3. Enass A. Abdel-Hameed, Hong Ji, Mohamed Tarek Shata
    Pages 27-38
  4. Hans Helmut Niller, Ferenc Banati, Daniel Salamon, Janos Minarovits
    Pages 39-69
  5. Janos Minarovits, Anett Demcsák, Ferenc Banati, Hans Helmut Niller
    Pages 71-90
  6. Lorenzo Chiariotti, Lorena Coretti, Raffaela Pero, Francesca Lembo
    Pages 91-105
  7. Hans Helmut Niller, Janos Minarovits
    Pages 107-130
  8. Back Matter
    Pages 131-137

About this book

Introduction

Epigenetic modification of cellular genomes is a fascinating means of regulating tissue- and cell type-specific gene expression in all developmental stages of the life of an organism. Carefully orchestrated processes, such as DNA methylation and a plenitude of specific histone modifications secure the faithful transmission of gene expression patterns to progeny cells. Upon chronic infection, the epigenetic cellular balance can become disrupted and, in the long run, through the epigenetic reprogramming of host cell genomes, contribute to the malignant conversion of formerly healthy cells, in many cases preceded by the establishment of an epigenetic field of cancerization. The present volume undertakes to highlight the interactions of infectious pathogens and their effector molecules with the epigenetic regulatory machinery of the cell. Clearly, the recent take-off of epigenetics research did not leave Research on Infectious Diseases and Infection-Associated Cancer untouched. This resulted in a great many of clinically relevant data on understanding the molecular mechanisms of chronic infectious disease. Infectious pathogen- and disease-specific epigenetic alterations are already being used for the early detection of malignant disease and for the prediction of chemotherapy resistance or response to treatment.

Keywords

Epigenetics Infectious Disease DNA methylation Histone modification Epstein-Barr virus (EBV) Human Immunodeficiency virus (HIV) lipopolysaccharides intracellular bacteria

Editors and affiliations

  • Janos Minarovits
    • 1
  • Hans Helmut Niller
    • 2
  1. 1.University of SzegedSzegedHungary
  2. 2.University of RegensburgRegensburgGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-24738-0
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-24736-6
  • Online ISBN 978-3-319-24738-0
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site