© 2016

Lung Cancer and Personalized Medicine

Current Knowledge and Therapies

  • Aamir Ahmad
  • Shirish Gadgeel


  • Succintly combines the most current research on lung cancer from epidemiology to recent breakthroughs in personalized therapies

  • Explores current targets, molecular profiling and biomarkers in lung cancer

  • Integrates basic research and clinical implications, fostering cross-disciplinary research and creating wide appeal


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 893)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Lindsey A. Torre, Rebecca L. Siegel, Ahmedin Jemal
    Pages 1-19
  3. Ann G. Schwartz, Michele L. Cote
    Pages 21-41
  4. Gabriel Alberto Rivera, Heather Wakelee
    Pages 43-57
  5. Lysanne Lievense, Joachim Aerts, Joost Hegmans
    Pages 59-90
  6. Stefano Cafarotti, Filippo Lococo, Patrizia Froesh, Francesco Zappa, Dutly Andrè
    Pages 127-136
  7. Jarushka Naidoo, Alexander Drilon
    Pages 155-178
  8. Sai-Hong Ignatius Ou, Keisuke Shirai
    Pages 179-187
  9. Eric S. Kim
    Pages 189-209
  10. Back Matter
    Pages 225-228

About this book


This, the first of two volumes on personalized medicine in lung cancer, touches on the core issues related to the understanding of lung cancer—statistics and epidemiology of lung cancer—along with the incidence of lung cancer in non-smokers. A major focus of this volume is the state of current therapies against lung cancer—immune, targeted therapies against EGFR TKIs, KRAS, ALK, angiogenesis; the associated challenges, especially resistance mechanisms; and recent progress in targeted drug development based on metal chemistry. Chapters are written by some of the leading experts in the field, who provide a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies.


ALK signaling EGFR signaling k-ras lung cancer therapy personalized therapy small cell lung cancer

Editors and affiliations

  • Aamir Ahmad
    • 1
  • Shirish Gadgeel
    • 2
  1. 1.Wayne State University, Karmanos Cancer InstituteDetroitUSA
  2. 2.Wayne State University, Karmanos Cancer InstituteDetroitUSA

About the editors

Aamir Ahmad, PhD, is a Scientist at the Wayne State University School of Medicine, Department of Pathology, and the Karmanos Cancer Institute. He has been a member of leading cancer organizations such as the American Association for Cancer Reseasrch and the Union for International Cancer Control. In addition to serving as a reviewer for a number of peer-reviewed scientific journals, he is currently a Section Editor for the journal PLoS ONE, for which he is responsible for policy drafts and the identification and management of special issues. Dr. Ahmad has published more than 100 scientific papers and has authored numerous book chapters. In addition to the current volume Dr. Ahmad served as the editor of two volumes published by Springer. 

Shirish M. Gadgeel, M.D. a Professor in the Department of Oncology at Karmanos Institute/Wayne State University in Detroit. He is the co-leader of the Molecular Therapeutics Program of Karmanos Cancer Institute and the leader of the Multidisciplinary Thoracic Oncology team. Dr. Gadgeel is a member of several professional societies, including the American Society of Clinical Oncology and the International Association for the Study of Lung Cancer. He currently serves on the Editorial Board of the journals Cancer and Clinical Lung Cancer. Dr. Gadgeel is a Principal Investigator of several trials focused on the treatment of Lung Cancer, and has published more than 80 scientific papers

Bibliographic information

  • Book Title Lung Cancer and Personalized Medicine
  • Book Subtitle Current Knowledge and Therapies
  • Editors Aamir Ahmad
    Shirish Gadgeel
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-24221-7
  • Softcover ISBN 978-3-319-79592-8
  • eBook ISBN 978-3-319-24223-1
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XIII, 228
  • Number of Illustrations 12 b/w illustrations, 14 illustrations in colour
  • Topics Cancer Research
    Molecular Medicine
    Internal Medicine
  • Buy this book on publisher's site
Industry Sectors
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Oncology & Hematology
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“The aim of this book is to discuss current knowledge about lung cancer with a specific focus on non-small-cell lung cancer (NSCLC). … The intended audience is established researchers, clinicians, healthcare professionals, and students in the medical and scientific community. … The authors have successfully compiled a well-written, comprehensive, and robust book about NSCLC … .” (Karen L. Reckamp, Doody’s Book Reviews, August, 2016)