Advertisement

Antimicrobial Peptides

Role in Human Health and Disease

  • Jürgen Harder
  • Jens-M. Schröder

Part of the Birkhäuser Advances in Infectious Diseases book series (BAID)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Fabian Garreis, Martin Schicht, Friedrich Paulsen
    Pages 17-32
  3. Frederik Seiler, Robert Bals, Christoph Beisswenger
    Pages 33-52
  4. Brian Becknell, John David Spencer
    Pages 53-65
  5. Maureen J. Ostaff, Eduard F. Stange, Jan Wehkamp
    Pages 67-88
  6. Alexander M. Cole, Amy Liese Cole
    Pages 115-127
  7. Kim Alan Brogden, Amber M. Bates, Carol L. Fischer
    Pages 129-146
  8. Back Matter
    Pages 155-158

About this book

Introduction

This book focuses on the importance of human antimicrobial peptides (AMP) in keeping the host healthy and preventing infectious diseases. The first chapters deal with several examples of the role of AMP in different epithelial organs (skin and wound healing, eye, lung, genito-urinary tract, gut), which are exposed to different kinds of infectious microorganisms and as a result produce different patterns of AMP. Examples of the dysregulation of AMP expression and function promoting infections are discussed. The capacity of AMP to restrict the availability of essential metals to bacteria as an efficient antibacterial strategy in nutritional immunity is discussed in the next chapter. Our current understanding of how vitamin D, the sunshine vitamin, influences AMP-expression and how this can affect our health is also addressed. Last but not least, the role of AMP in HIV infection and the immunomodulatory properties of AMP highlight the diverse facets of AMP in host immunity. AMP’s specific functions, including in fighting multi-resistant bacteria, suggest that they may offer therapeutic benefits – a question that is discussed in the final chapter.

Keywords

Antimicrobial peptides (AMP) in health and disease antimicrobial proteins defensins endogenous peptide antibiotics host defense peptides innate host defense innate immunity

Editors and affiliations

  • Jürgen Harder
    • 1
  • Jens-M. Schröder
    • 2
  1. 1.Department of DermatologyUniversity-Hospital Schleswig-Holstein, Campus KielKielGermany
  2. 2.Department of DermatologyUniversity-Hospital Schleswig-Holstein, Campus KielKielGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-24199-9
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-24197-5
  • Online ISBN 978-3-319-24199-9
  • Series Print ISSN 2504-3811
  • Series Online ISSN 2504-3838
  • Buy this book on publisher's site
Industry Sectors
Biomedicine
Pharma
Health & Hospitals
Biotechnology