Alpha-1 Antitrypsin

Role in Health and Disease

  • Adam Wanner
  • Robert A. Sandhaus

Part of the Respiratory Medicine book series (RM)

Table of contents

  1. Front Matter
    Pages i-x
  2. Robin Carrell
    Pages 1-15
  3. Bethany Lussier, Andrew A. Wilson
    Pages 17-30
  4. Adriano R. Tonelli, Farshid Rouhani, Mark L. Brantly
    Pages 85-98
  5. Robert A. Sandhaus
    Pages 99-110
  6. Amitava Mukherjee, Souvik Chakraborty, Yan Wang, Andy Chu, David Perlmutter
    Pages 111-140
  7. Back Matter
    Pages 171-173

About this book


This book offers a comprehensive overview of alpha-1 antitrypsin deficiency, an inherited condition that leads to lung disease in adults and liver disease in adults and children. While it is a rare condition, the mechanisms underlying its clinical manifestations have been largely clarified. Specific treatment, however, is available only for the lung disease that arises from the condition, thus necessitating continued research into new and alternative therapeutic solutions. The book discusses the biology of alpha-1 antitrypsin, protein misfolding and polymerization, and diagnosis and treatment of alpha-1 antitrypsin deficiency and its associated diseases.  It concludes with a discussion of  alpha-1 antitrypsin therapy in diseases not associated with alpha-1 antitrypsin deficiency, and the role of healthcare organizations in the rare disease space. Written for pulmonary clinicians and scientists, Alpha-1 Antitrypsin: Role in Health and Disease is a valuable resource that sheds light on this rare disease. 


Genetic mutations Liver Disease Lung Disease Protein misfolding Rare diseases Serpins

Editors and affiliations

  • Adam Wanner
    • 1
  • Robert A. Sandhaus
    • 2
  1. 1.University of Miami Miller School of MedicineMiamiUSA
  2. 2.National Jewish Health DENVERUSA

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Humana Press, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-23448-9
  • Online ISBN 978-3-319-23449-6
  • Series Print ISSN 2197-7372
  • Series Online ISSN 2197-7380
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology