© 2015

microRNA: Basic Science

From Molecular Biology to Clinical Practice

  • Gaetano Santulli


  • Focuses on innovative applications of microRNAs to obtain selective therapies in several disorders, not centered on cell proliferation and cancer

  • Includes distinguished experts in the field, from prominent universities and with a strong record of scientific publications

  • Provides systematic and extensive discussions of both biological features and clinical applications


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 887)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Thomas C. Roberts
    Pages 15-30
  3. Pedro M. Borralho, Cecília M. P. Rodrigues, Clifford J. Steer
    Pages 31-51
  4. Jan Novák, Veronika Olejníčková, Nikola Tkáčová, Gaetano Santulli
    Pages 79-100
  5. Sabire Özcan
    Pages 101-117
  6. Massimiliano Gnecchi, Federica Pisano, Riccardo Bariani
    Pages 119-141
  7. Henry H. Chill, Uri P. Dior, Liron Kogan, Ariel Revel
    Pages 143-155
  8. Ye Yuan, Lingying Tong, Shiyong Wu
    Pages 157-170
  9. Hanuma Kumar Karnati, Sanjeev Raghuwanshi, Shilpa Sarvothaman, Usha Gutti, Raja Gopal Venakata Saladi, Jaswant Kumar Komati et al.
    Pages 171-211
  10. Xurde M. Caravia, Carlos López-Otín
    Pages 213-230
  11. Alessandro Laganà
    Pages 231-252
  12. Gaetano Santulli
    Pages E1-E2
  13. Back Matter
    Pages 253-257

About this book


This volume explores microRNA pathophysiology, focusing on basic concepts in molecular and cellular biology. Chapters contributed by leading scientists examine recently discovered pathways in several processes, including aging, diabetes, cardiovascular disease, hematopoiesis, and mitochondrial fitness. The authors contextualize microRNAs within epigenetics and micropeptidomics, angiongenesis and atherosclerosis, endometrial pathophysiology, and more. Throughout, numerous color photographs, diagrams of molecular pathways, and tables enhance the text.

microRNA: Basic Science is an ideal companion to both microRNA: Medical Evidence and microRNA: Cancer. Taken together, these three books provide a state-of-the-art overview of this rapidly-expanding and fascinating field, from the molecular level to clinical practice. It will be invaluable to medical students, physicians, and researchers, as a complete and unique guide in the exploration of microRNA in basic science, cancer and clinical practice.


Clinical practice Epigenetics Physiology Selective treatments Targeted therapy microRNA

Editors and affiliations

  • Gaetano Santulli
    • 1
  1. 1.Columbia University Medical CenterNew YorkUSA

About the editors

Dr. Gaetano Santulli received his MD and PhD at the University of Naples “Federico II”. A physician scientist, Dr. Santulli completed his postdoctoral training at Columbia University Medical Center in New York City, supported by an AHA fellowship and a Scientist Development Grant. Cardiologist, he authored more than 100 publications, including peer-reviewed articles in high impact journals, book chapters, and medical books. He is currently a faculty member of Columbia University. He lives in Manhattan.

Dr. Santulli’s expertise comprises both clinical and basic research topics, including hypertension, diabetes, angiogenesis, heart failure, arrhythmias, vascular disorders, and skeletal muscle disease. He is a member of several international academic societies, including New York Academy of Sciences, American Heart Association (AHA), American Diabetes Association, European Society of Cardiology, Endocrine Society, American Association for the Advancement of Science, European Association of Heart Failure, European Association of Echocardiography, Acute Cardiovascular Care Association, European Association of Percutaneous Cardiovascular Interventions. He serves on the Editorial Boards of numerous medical Journals.

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