Engineering Mineralized and Load Bearing Tissues

  • Luiz E. Bertassoni
  • Paulo G. Coelho

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 881)

Table of contents

  1. Front Matter
    Pages i-x
  2. Fabrication Methods and Techniques

    1. Front Matter
      Pages 1-1
    2. Claire G. Jeong, Anthony Atala
      Pages 3-14
    3. Chia-Cheng Li, Mahshid Kharaziha, Christine Min, Richard Maas, Mehdi Nikkhah
      Pages 15-31
    4. Jose V. Araujo, Pedro P. Carvalho, Serena M. Best
      Pages 33-53
  3. Applied Strategies for Tissue Engineering: Bone and Cartilage

    1. Front Matter
      Pages 55-55
    2. Brandon T. Smith, Jonathan Shum, Mark Wong, Antonios G. Mikos, Simon Young
      Pages 57-78
    3. Giada D. G. Barabaschi, Vijayan Manoharan, Qing Li, Luiz E. Bertassoni
      Pages 79-94
    4. Seyedsina Moeinzadeh, Esmaiel Jabbari
      Pages 95-110
    5. Paulo G. Coelho, Marcelo Suzuki, Charles Marin, Rodrigo Granato, Luis F. Gil, Nick Tovar et al.
      Pages 111-128
    6. Sriram Ravindran, Anne George
      Pages 129-142
    7. Clara R. Correia, Rui L. Reis, João F. Mano
      Pages 143-160
    8. Ali Negahi Shirazi, Wojciech Chrzanowski, Ali Khademhosseini, Fariba Dehghani
      Pages 161-186
    9. Oliver E. Armitage, Michelle L. Oyen
      Pages 187-204
  4. Applied Strategies for Tissue Engineering: Dentin, Enamel, Cementum and PDL

    1. Front Matter
      Pages 205-205
    2. Danijela Menicanin, K. Hynes, J. Han, S. Gronthos, P. M. Bartold
      Pages 207-236
    3. Vuk Uskoković
      Pages 237-254
    4. Masamitsu Oshima, Takashi Tsuji
      Pages 255-269
  5. Back Matter
    Pages 271-276

About this book


This book offers a comprehensive overview of current challenges and strategies to regenerate load-bearing and calcified human tissues, including bone, cartilage,tendon, ligaments and dental structures (dentin, enamel, cementum and periodontal ligament). Tissue engineering has long held great promises as an improved treatment option for conditions affecting mineralized and load-bearing structures in the body. Although significant progress has been achieved in recent years, a number of challenges still exist.

Scaffold vascularization, new biofabrication methods (3D printing, lithography, microfabrication), peptide conjugation methods, interface engineering, scaffold mechanical properties, iPS cells, organs-on-a-chip, are some of the topics discussed in this book. More specially, in the first section readers will find an overview of emerging biofabrication methods. In section 2, applied strategies for regeneration of (2.1) bone, cartilage and ligament, as well as (2.2) dentin, cementum, enamel and periodontal ligament are discussed across 14 chapters.

While other volumes have addressed the regeneration of individual tissues, or exclusively focused on different regenerative strategies, the focus of this work is to bring together researchers integrating backgrounds in materials sciences, engineering, biology, mechanics, fluidics, etc, to address specific challenges common to regeneration of several load-bearing and calcified tissues. Therefore, this book provides a unique platform to stimulate progress in the regeneration of functional tissue substitutes.

We envision that this book will represent a valuable reference source for university and college faculties, post-doctoral research fellows, senior graduate students, and researchers from R&D laboratories in their endeavors to fabricate biomimetic load bearing tissues.


bone and cartilage dentistry load bearing tissues mineralized tissues tissue engineering

Editors and affiliations

  • Luiz E. Bertassoni
    • 1
  • Paulo G. Coelho
    • 2
  1. 1.Center for Regenerative MedicineOregon Health and Science UniversityPortlandUSA
  2. 2.Department of Biomaterials and BiomimeticsNew York UniversityNew YorkUSA

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