Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine

  • Christophe Le Tourneau
  • Maud Kamal

Table of contents

  1. Front Matter
    Pages i-x
  2. Gaëlle Pierron
    Pages 15-30
  3. Nicolas Servant, Philippe Hupé
    Pages 69-99
  4. Etienne Rouleau, Céline Callens, Gaëlle Pierron, Ivan Bièche
    Pages 101-112
  5. Xavier Paoletti, Bernard Asselain, Christophe Le Tourneau
    Pages 113-131

About this book


This original book provides readers with an overview of the latest developments in personalized medicine clinical trials in oncology. The topics covered range from the rationale behind this new generation of clinical trials and the latest statistical models for high-throughput molecular techniques, bioinformatics, high-throughput screening molecular techniques and the challenges entailed by implementing them in daily practice. It also covers the key role of pathology in the validation of molecular results and the complex assessment of predictive biomarkers. The different topics covered are supplemented by unique concrete examples based on the SHIVA trial.

The authors are all members of the French Curie Institute, one of the world’s foremost cancer research institutions.


Bioinformatics Cancer personalized medicine High throughput screening techniques Pathology Predictive biomarkers

Editors and affiliations

  • Christophe Le Tourneau
    • 1
  • Maud Kamal
    • 2
  1. 1.Institut CurieDepartment of Medical OncologySaint-Cloud & ParisFrance
  2. 2.Institut CurieDepartment of Medical OncologySaint-Cloud & ParisFrance

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-22188-5
  • Online ISBN 978-3-319-22189-2
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals