Antiepileptic Drugs and Pregnancy

A Guide for Prescribers

  • MJ Eadie
  • FJE Vajda

Table of contents

  1. Front Matter
    Pages i-xii
  2. MJ Eadie, FJE Vajda
    Pages 1-4
  3. MJ Eadie, FJE Vajda
    Pages 5-13
  4. Antiepileptic Drug Pharmacokinetics in Pregnancy

    1. Front Matter
      Pages 15-15
    2. MJ Eadie, FJE Vajda
      Pages 17-26
    3. MJ Eadie, FJE Vajda
      Pages 27-66
    4. MJ Eadie, FJE Vajda
      Pages 67-85
    5. MJ Eadie, FJE Vajda
      Pages 87-108
  5. Antiepileptic Drugs and the Foetus

    1. Front Matter
      Pages 109-109
    2. MJ Eadie, FJE Vajda
      Pages 111-127
    3. MJ Eadie, FJE Vajda
      Pages 175-189
  6. Antiepileptic Drug Use and Pregnancy

    1. Front Matter
      Pages 191-191
    2. MJ Eadie, FJE Vajda
      Pages 215-220
  7. Back Matter
    Pages 221-232

About this book


A description of our current understanding of antiepileptic drug use during pregnancy, this book includes chapters on the impact of seizures on the mother and developing child, changes in maternal physiology during pregnancy and its impact on drug disposition, and the pharmacokinetic differences between the various anti-seizure medications. It also deals with the possible harmful effects of antiepileptic drug exposure during pregnancy on the physical and intellectual development of the fetus. Clinicians have to balance the potential adverse effects of the medicine for the fetus and mother-to-be against the risks that uncontrolled seizures hold for both when treating pregnant women with antiepileptic drugs. Only recently have enough scientific data emerged to provide a rational basis for treatment decisions that take in both aspects. This work provides a single, accessible, and up-to-date resource for busy clinicians.


Anti-Seizure Medications Anticonvulsants Breast Feeding Drug Interactions Epilepsy Fertility Fetal Malformation Pharmacokinetics Pharmacology Pharmacovigilance Prescribing Risk Safety Seizures Sex Sexual Function Teratogenic

Authors and affiliations

  • MJ Eadie
    • 1
  • FJE Vajda
    • 2
  1. 1.Emeritus Professor of Clinical Neurology and Neuropharmacology, University of Queensland, and Honorary Consultant Neurologist, Royal Brisbane and Women's hospitalBrisbaneAustralia
  2. 2.Department of Medicine and NeurologyDirector of the Australian Epilepsy and Pregnancy Register, University of Melbourne and Royal Melbourne HospitalMelbourneAustralia

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Adis, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-21433-7
  • Online ISBN 978-3-319-21434-4
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals