© 2015

Stem Cells in the Lung

Development, Repair and Regeneration

  • Ivan Bertoncello


  • Presents a comprehensive overview of the current understanding of the organization of endogenous lung stem and progenitor cell compartments from fetal development, postnatal growth and in adulthood

  • Scope is deliberately focused on taking a cellular perspective, rather than the molecular perspective covered elsewhere

  • Excludes any discussion of lung cancer so topic is covered in depth and does not overlap within the literature


Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Fetal Lung Development

    1. Front Matter
      Pages 1-1
    2. Bernard Thébaud, Mervin C. Yoder
      Pages 25-41
    3. Alan J. Burns, Lucy J. Freem, Jean-Marie Delalande
      Pages 43-62
    4. Foula Sozo, Megan O’Reilly, Richard Harding
      Pages 63-94
  3. Adult Lung Stem and Progenitor Cells

    1. Front Matter
      Pages 95-95
    2. Ahmed E. Hegab, Tomoko Betsuyaku, Brigitte N. Gomperts
      Pages 97-112
    3. Robert E. Hynds, Adam Giangreco
      Pages 113-126
    4. Andrew M. Hoffman
      Pages 127-145
  4. Regulation of Lung Regeneration and Repair

    1. Front Matter
      Pages 147-147
    2. Jonathan L. McQualter
      Pages 149-158
    3. Jonathan L. McQualter, Desiree Anthony, Ross Vlahos, Steven Bozinovski
      Pages 159-168
    4. Connie C. W. Hsia, Priya Ravikumar
      Pages 191-210
  5. Cellular Therapies for Lung Disease

    1. Front Matter
      Pages 211-211
    2. Vibha N. Lama
      Pages 213-223
    3. Mervin C. Yoder, Bernard Thébaud
      Pages 243-263

About this book


This comprehensive overview of endogenous lung stem and progenitor cell organization and regulation in fetal lung development, postnatal lung growth and adulthood deftly compiles and explores the current body of research. Progressing stage by stage, the chapters on fetal lung development emphasize the integrated role of epithelial, stromal, vascular and neural cell elements in building a functional lung, while the subsequent chapters on adult lung regeneration describe the nature and properties of adult lung stem/progenitor cells distributed along the proximal-distal axis of the airway tree. The chapters on regulation of lung regeneration and repair discuss how regenerative cells interact with their niche microenvironment and how regulation of lung regeneration and repair in the steady state and following injury recapitulates ontogeny. And, lastly, the chapters on cellular therapies for lung disease and bioengineering the lung focus on promising emerging therapies and approaches in lung regenerative medicine.

The scope of this volume of the Stem Cell Biology and Regenerative Medicine series focuses on exploring the topic of building and rebuilding the lung from a cellular rather than a molecular perspective. All of the contributors are working at the cutting edge of the lung stem cell field, making Stem Cells in the Lung essential reading for those with an interest in the field of lung stem cell biology and the potential role of cellular therapies and tissue bioengineering approaches in lung regenerative medicine, including biomedical scientists, graduate students, post-graduate researchers and respiratory clinicians.


bronchiolar airways cellular therapy lung regeneration progenitor cells vasculogenesis

Editors and affiliations

  • Ivan Bertoncello
    • 1
  1. 1.Lung Health Research Centre, Department of Pharmacology and TherapeuticsUniversity of MelbourneMelbourneAustralia

About the editors

Ivan Bertoncello, MSc, PhD is an Honorary Principle Research Fellow and Associate Professor in the Department of Pharmacology and Therapeutics; and a member of the executive of the Lung Health Research Centre, at the University of Melbourne, Victoria, Australia. He has previously held appointments as Head of the Adult Lung Stem Cell Laboratory at the Australian Stem Cell Centre at Monash University; and Head of the Lung Regeneration Laboratory in the Department of Pharmacology and Therapeutics at the University of Melbourne. His international reputation in stem cell research was originally built on pioneering studies analysing the organisation and regulation of bone marrow stem and progenitor cells. His laboratory employed similar methods to analyse endogenous adult lung stem and progenitor cells in order to understand how regenerative cells in the adult lung are organised, and how they can be harnessed to treat lung disease or repair the injured lung.

Bibliographic information

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