© 2015

Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations

  • Ellen Hsu
  • Louis Du Pasquier

Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 57)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Robert S. Jack
    Pages 1-20
  3. Pathogens: Antigen Repertoires and Variations

    1. Front Matter
      Pages 21-21
    2. Galadriel Hovel-Miner, Monica Mugnier, F. Nina Papavasiliou, Jason Pinger, Danae Schulz
      Pages 23-46
    3. Michaela Petter, Michael F. Duffy
      Pages 47-90
  4. Hosts: Anticipatory and Adapting Mechanisms

    1. Front Matter
      Pages 109-109
    2. Assunta Liberti, Brittany Leigh, Rosaria De Santis, Maria Rosaria Pinto, John P. Cannon, Larry J. Dishaw et al.
      Pages 159-173
    3. Masanori Kasahara
      Pages 175-192
    4. Eva Bengtén, Melanie Wilson
      Pages 193-234
    5. Victoria L. Hansen, Robert D. Miller
      Pages 265-278
    6. Dennis K. Lanning, Katherine L. Knight
      Pages 279-293
    7. Kate Senger, Jason Hackney, Jian Payandeh, Ali A. Zarrin
      Pages 295-324
  5. Back Matter
    Pages 325-336

About this book


This volume provides in-depth reviews of model systems that exemplify the arms race in host-pathogen interactions. Somatic adaptations are responsible for the individualization of biological responses to the environment, and the continual struggle between host immune systems and invading pathogens has given rise to corresponding processes that produce molecular variation. Whether in mollusks or human beings, various host somatic mechanisms have evolved independently, providing responses to counter rapidly-changing pathogens. The pathways they utilize can include non-heritable changes involving RNA and post-translational modifications, or changes that produce somatic DNA recombination and mutation. For infectious organisms such as protozoans and flatworms, antigenic variation is central to their survival strategy. Evolving the ability to evade the host immune system not only increases their chances of survival but is also necessary for successful re-infection within the host population.


Antibody repertoire Antigenic variation Host somatic mechanism Host-pathogen interactions Lymphocyte receptors Vertebrate immunity

Editors and affiliations

  • Ellen Hsu
    • 1
  • Louis Du Pasquier
    • 2
  1. 1.Department of Physiology and PharmacologySUNY Downstate Medical CenterBrooklynUSA
  2. 2.Institute of Zoology and Evolutionary BiologyUniversity of BaselBaselSwitzerland

Bibliographic information

  • Book Title Pathogen-Host Interactions: Antigenic Variation v. Somatic Adaptations
  • Editors Ellen Hsu
    Louis Du Pasquier
  • Series Title Results and Problems in Cell Differentiation
  • Series Abbreviated Title Results Cell Differentiation
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-20818-3
  • Softcover ISBN 978-3-319-37182-5
  • eBook ISBN 978-3-319-20819-0
  • Series ISSN 0080-1844
  • Series E-ISSN 1861-0412
  • Edition Number 1
  • Number of Pages VIII, 336
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Immunology
    Evolutionary Biology
    Cell Biology
  • Buy this book on publisher's site
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