© 2015

Bioactive Sphingolipids in Cancer Biology and Therapy

  • Yusuf A. Hannun
  • Chiara Luberto
  • Cungui Mao
  • Lina Marie Obeid


  • Examines the roles and functions of sphingolipids in the development, progression and treatment of various cancers

  • Explores the use of innovative approaches for quantitative analysis and imaging which could have the potential benefit of helping to develop novel cancer therapeutics

  • Appeals to researchers in the fields of cancer and lipid metabolism/signaling


Table of contents

  1. Front Matter
    Pages i-xi
  2. Céline Colacios, Frédérique Sabourdy, Nathalie Andrieu-Abadie, Bruno Ségui, Thierry Levade
    Pages 1-20
  3. Roles and Functions of Sphingolipids in the Development of Different Types of Cancers

    1. Front Matter
      Pages 21-21
    2. Hirofumi Sawai, Makoto Taniguchi, Toshiro Okazaki
      Pages 23-51
    3. Chih-Li Lin, Cungui Mao
      Pages 107-122
    4. David Garandeau, Marguerite Mrad, Thierry Levade, Cristiana Perrotta, Nathalie Andrieu-Abadie, Mona Diab-Assaf
      Pages 123-139
    5. Hideki Furuya, Songhwa Choi, Lina M. Obeid, Toshihiko Kawamori, Ashley J. Snider
      Pages 141-159
    6. Eva M. Schmelz, Hui Zhou, Paul C. Roberts
      Pages 161-188
    7. Carmen Garcia-Ruiz, Albert Morales, José C. Fernández-Checa
      Pages 189-209
    8. Samy A. F. Morad, Myles C. Cabot
      Pages 211-233
    9. Loubna Abdel Hadi, Clara Di Vito, Giovanni Marfia, Stefania Elena Navone, Rolando Campanella, Laura Riboni
      Pages 259-293
  4. Emerging Technologies for Sphingolipid Detection and Prediction of Modulation of Sphingolipid Metabolism

    1. Front Matter
      Pages 295-295
    2. Xinghua Lu, W. Jim Zheng, Yusuf A. Hannun
      Pages 297-311
    3. Nadia A. Rana, Ashutosh Singh, Maurizio Del Poeta, Yusuf A. Hannun
      Pages 313-338
    4. E. Ellen Jones, Shaalee Dworski, Mustafa Kamani, Daniel Canals, Masayuki Wada, Xiang Liu et al.
      Pages 339-358
    5. Bruce A. Stanley, Tye Deering, Todd E. Fox
      Pages 359-384

About this book


This volume presents information on both the basic and clinical aspects of sphingolipid-metabolizing enzymes in various cancers. The volume also includes discussions of the innovative techniques and approaches for quantitative analysis and imaging that could significantly impact the general understanding of this topic, and the potential benefit of targeting sphingolipid enzymes to develop novel cancer therapeutics. As well, the volume includes a critical examination of the specific pathways and pathobiologies associated with the altered regulation of sphingolipid metabolism as a contributor to the development and/or maintenance of pathological conditions such as cancer.


bioactive molecules ceramide-based lipids ceramides glycosphingolipids signaling cascades

Editors and affiliations

  • Yusuf A. Hannun
    • 1
  • Chiara Luberto
    • 2
  • Cungui Mao
    • 3
  • Lina Marie Obeid
    • 4
  1. 1.Stony Brook UniversityStony Brook Cancer CenterStony BrookUSA
  2. 2.Dept. of Physiology & BiophysicsStony Brook UniversityStony BrookUSA
  3. 3.Dept. of MedicineStony Brook UniversityStony BrookUSA
  4. 4.Dept. of MedicineStony Brook UniversityStony BrookUSA

About the editors

Yusuf A. Hannun, MD, is Director, Stony Brook Cancer Center, Vice Dean, Cancer Medicine, and Professor, Biochemistry and Cell Biology, Stony Brook University. He is a renowned molecular biologist and physician-scientist investigating the molecular mechanisms of cancer, with an expertise in sphingolipids. Dr. Hannun is currently on the Editorial Board of several journals, including Biomedicine and Biotechnology, Frontiers in Membrane Physiology, and Biophysics, Chemistry and Physics of Lipids, and has received several honors, including the ASBMB Avanti Award in Lipids and ISI Highly Citied Researchers (in Biology and Biochemistry), and is Fellow, the American Association and Advancement of Science. He has published 448 scientific papers, which have received more than 34,100 citations.


Chiara Luberto, Ph.D., is Research Associate Professor of Physiology and Biophysics, Stony Brook University.


Cungui Mao, Ph.D., is Associate Professor of Medicine, Stony Brook University.


Lina Marie Obeid, M.D., is Professor of Medicine and Dean of Research, Stony Brook University.

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