© 2015

Infection and Cancer: Bi-Directorial Interactions

  • Michael R. Shurin
  • Yasmin Thanavala
  • Nahed Ismail
  • Summarizes current knowledge on co-development of infectious diseases and cancer

  • Supports understanding of pathways involved in the progression of infection and cancer

  • Presents both experimental animal results and human clinical data


Table of contents

  1. Front Matter
    Pages i-vi
  2. Michael R. Shurin, Jinbao Zong, Anton A. Keskinov
    Pages 1-10
  3. Infection-Associated Cancers

    1. Front Matter
      Pages 11-11
    2. Joseph S. Pagano
      Pages 13-22
    3. Jessica Liu, Hwai-I Yang, Mei-Hsuan Lee, Wan-Lun Hsu, Hui-Chi Chen, Chien-Jen Chen
      Pages 23-47
    4. Marianna Agassandian, Galina V. Shurin
      Pages 49-74
    5. Raavi Gupta, Maja Nowakowski, M. A. Haseeb
      Pages 75-91
    6. Aditya Reddy, Bernard Fried
      Pages 93-107
    7. Dmitriy W. Gutkin
      Pages 109-131
    8. Jotham Suez, Maayan Levy, Christoph A. Thaiss, Eran Elinav
      Pages 151-167
  4. Infection-Associated Cancers: Specific Examples

    1. Front Matter
      Pages 169-169
    2. Jyoti Mishra, Paolo Ruggiero, Fabio Bagnoli, Rino Rappuoli, Markus Stein
      Pages 171-211
    3. Jukka H. Meurman, Antonio Bascones-Martinez
      Pages 213-230
    4. Salvatore Galdy
      Pages 231-241
    5. Antonio Carlos de Freitas, Ana Pavla Almeida Diniz Gurgel, Bárbara Simas Chagas, Carolina Maria Medeiros do Amaral, Eliane Campos Coimbra, Élyda Gonçalves de Lima et al.
      Pages 243-291
  5. Cancer-Associated Infections

    1. Front Matter
      Pages 293-293
    2. Tatiana Zorina, Alexis Styche
      Pages 295-311
  6. Infection and Cancer: Comorbid Development

    1. Front Matter
      Pages 313-313
    2. Nahed Ismail, Michael R. Shurin, Abdulrahman Zaghloul
      Pages 315-332

About this book


This unique book summarizes current knowledge on co-development of infectious diseases and cancer. It provides an overview of the complex and unique role of the immune system, inflammation, tumor-mediated immunosuppression and infection-induced immunomodulation in cancer and infection progression.


Chapters are organized into themed parts, beginning with a look at the historical perspective of human tumor viruses, then aspects and examples of infection-related cancers and cancer-associated infections. The work discusses how cancer- and infection-associated immune responses interact in a bi-directorial fashion and how these interactions may evolve during both disease progression and in response to therapy. The phenomenon of independent development of cancer and infection in the same host, known as comorbid cancer-infection progression, is explored.


Understanding the complex pathways involved in the progression of infection and cancer will allow the prevention of the development of certain types of cancer, as well as advancing prophylactic anti-cancer vaccines. Readers of this work will discover innovative approaches for multidisciplinary projects, focusing on the design of original therapeutic modalities for cancer therapy. The book will therefore be particularly valuable to scholars interested in cancer immunology and researchers and clinicians in the field of basic and applied immunobiology and microbiology.



Cancer immunology Cancer-mediated immunomodulation Tumor immunobiology Tumor microenvironment cancer-associated infections infection-induced tumors infectious diseases

Editors and affiliations

  • Michael R. Shurin
    • 1
  • Yasmin Thanavala
    • 2
  • Nahed Ismail
    • 3
  1. 1.Department of PathologyUniversity of Pittsburgh Medical CenterPittsburghUSA
  2. 2.Department of ImmunologyRoswell Park Cancer InstituteBuffaloUSA
  3. 3.Department of PathologyUniversity of Pittsburgh Medical CenterPittsburghUSA

Bibliographic information

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