Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones

  • Robert Doran

Part of the Springer Theses book series (Springer Theses)

About this book


This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereocontrol, which is significant because it allows the configuration of a new stereocentre to be controlled by a simple change of proton source.


Antimicrobial Activity Asymmetric Synthesis Catalytic Asymmetric Synthesis Dual Stereocontrol Natural Product Analogues Total Synthesis

Authors and affiliations

  • Robert Doran
    • 1
  1. 1.Department of ChemistryImperial College LondonLondonUnited Kingdom

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