© 2015

Electrophysiology of Unconventional Channels and Pores

  • Anne H. Delcour

Part of the Springer Series in Biophysics book series (BIOPHYSICS, volume 18)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Mitochondria

    1. Front Matter
      Pages 1-1
    2. Tatiana K. Rostovtseva, Sergey M. Bezrukov
      Pages 3-31
    3. Richard Wagner, David Schmedt, Patrizia Hanhart, Claudius Walter, Christof Meisinger, Philipp Bartsch
      Pages 33-58
    4. Kathleen W. Kinnally, Pablo M. Peixoto
      Pages 59-74
    5. Marco Colombini
      Pages 75-98
  3. Bacteria and Viruses

    1. Front Matter
      Pages 99-99
    2. Vicente M. Aguilella, María Queralt-Martín, Antonio Alcaraz
      Pages 101-121
    3. Thieng Pham, Anne H. Delcour
      Pages 123-151
    4. Joseph M. Hyser
      Pages 153-181
  4. Toxins and Antimicrobial Peptides

    1. Front Matter
      Pages 183-183
    2. Daria Stroukova, Jeremy H. Lakey
      Pages 185-208
    3. Nejc Rojko, Manuela Zanetti, Gregor Anderluh, Mauro Dalla Serra
      Pages 267-286
  5. Other Unconventional Channels

    1. Front Matter
      Pages 287-287
    2. Robert J. C. Gilbert
      Pages 289-312
    3. Rustam Azimov, Bruce L. Kagan
      Pages 343-360

About this book


This book is dedicated to the channels and pores that belong to an eclectic and ubiquitous class of unconventional - perhaps at times strange - pore-forming molecules, which nevertheless play fundamental roles in various organisms. These non-canonical channels may take on various and sometimes complex architectures, such as large beta-barrels or lipid-containing pores. They may originate from bacteria, viruses or intracellular organelles. For some of them, the physiologically relevant substrate may indeed be ions, and for others folded polypeptides. Some are released by cells in a soluble form that has the ability to insert into biological membranes to exert its permeabilizing effect. Many of these unconventional pores have been investigated by electrophysiology, which, by its virtue of focusing on a few or even a single unit, has provided invaluable insight into the mechanisms and structure-function relationships of these remarkable membrane entities. The chapters of this book highlight a representative set of these interesting investigations.


electrophysiology membrane channels non-canonical channels patch clamp pore forming unconventional pores

Editors and affiliations

  • Anne H. Delcour
    • 1
  1. 1.Department of Biology and BiochemistryUniversity of HoustonHoustonUSA

Bibliographic information