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Computational Modelling of the Human Islet Amyloid Polypeptide

  • Katrine Kirkeby┬áSkeby
Book
  • 1.2k Downloads

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Katrine Kirkeby Skeby
    Pages 1-30
  3. Katrine Kirkeby Skeby
    Pages 31-42
  4. Katrine Kirkeby Skeby
    Pages 43-61
  5. Katrine Kirkeby Skeby
    Pages 63-86
  6. Katrine Kirkeby Skeby
    Pages 101-108
  7. Katrine Kirkeby Skeby
    Pages 109-112
  8. Back Matter
    Pages 113-118

About this book

Introduction

This thesis offers readers a comprehensive introduction to amyloid proteins and the computational methods used with them. Katrine Skeby critically assesses and compares both the literature and the experiments performed by other researchers, which further elevates the quality and relevance of her own work. Amyloid proteins are highly complex, and this research provides unparalleled insights, especially with regard to the origin of cytotoxicity and to developing technologies for early detection, revealing in detail the molecular mechanisms behind hIAPP behavior. Several studies within the thesis answer difficult questions which promote future research into the properties of amyloid proteins.

Keywords

Alzheimer's disease Amylin Amyloid Amyloid fibrils Free energy calculations Human islet amyloid polypeptide Imaging agents, type 2 diabetes mellitus Molecular dynamics simulations Protofibrils

Authors and affiliations

  • Katrine Kirkeby┬áSkeby
    • 1
  1. 1.Department of Chemistry and theAarhus UniversityAarhus CDenmark

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-20040-8
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-319-20039-2
  • Online ISBN 978-3-319-20040-8
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
  • Buy this book on publisher's site
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