Studies on Experimental Toxicology and Pharmacology

  • Stephen M. Roberts
  • James P. Kehrer
  • Lars-Oliver Klotz

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Toxicological Mechanisms and Evaluation of Oxidative Stress

    1. Front Matter
      Pages 1-1
    2. Ethiene Castellucci Estevam, Muhammad Jawad Nasim, Lisa Faulstich, Marina Hakenesch, Torsten Burkholz, Claus Jacob
      Pages 3-20
    3. James P. Kehrer, Lars-Oliver Klotz, Stephen M. Roberts
      Pages 21-27
    4. Norsyahida Mohd Fauzi, Corinne M. Spickett
      Pages 43-79
    5. Sandra Reeg, Tilman Grune
      Pages 81-102
    6. Vasiliki I. Hatzi, Danae A. Laskaratou, Ifigeneia V. Mavragani, Gabriel E. Pantelias, Georgia I. Terzoudi, Alexandros G. Georgakilas
      Pages 103-129
    7. Lou Ann S. Brown, Dean P. Jones
      Pages 131-147
    8. Susannah Havermann, Christian Büchter, Karoline Koch, Wim Wätjen
      Pages 173-198
  3. Agents That Produce Toxicity: Mechanisms and Therapeutic Interventions

    1. Front Matter
      Pages 199-199
    2. Juliane I. Beier, Gavin E. Arteel
      Pages 213-232
    3. Abdullah Al Maruf, Peter J. O’Brien
      Pages 233-249
    4. Georgia K. Hinkley, Stephen M. Roberts
      Pages 251-266
    5. Francesca Aiello, Fedora Grande, Claudia Sticozzi, Giuseppe Valacchi
      Pages 303-321
    6. Erik J. Tokar, Wei Qu, Rachel J. Person, Olive N. Ngalame, Michael P. Waalkes
      Pages 323-334
    7. Vamsi Kodali, Brian D. Thrall
      Pages 347-367
    8. Uri Wormser, Yoram Finkelstein, Elena Proscura, Berta Brodsky, Michael Aschner
      Pages 369-379
  4. Special Topics

  5. Back Matter
    Pages 495-498

About this book


This book focuses on data describing the roles of free radicals and related reactive species, and antioxidants, in the causes and treatments of diseases, examining both clinical and pre-clinical trials, as well as basic research. The book is divided into sub-sections with chapters on toxicological mechanisms, agents that produce toxicity, and special topics including areas such as antioxidant supplements, oxygen toxicity, toxicogenomics, and marine biology.

Studies on Experimental Toxicology and Pharmacology promotes the concept of using biomarkers of free radical- and reactive species-induced injury as adjuncts to classical laboratory testing and the ability of antioxidants to provide cellular protection. There is increasing evidence that free radicals and other reactive species are causative, or at least supporting factors, that impact organisms and cause numerous tissue disorders.

With contributions from international experts in the field, this volume is a valuable resource for researchers and postgraduate students in toxicology and related fields, as well as clinicians and clinical researchers.


Antioxidants Carcinogenicity Oxidative Stress Pollutants Toxic agents Toxicity

Editors and affiliations

  • Stephen M. Roberts
    • 1
  • James P. Kehrer
    • 2
  • Lars-Oliver Klotz
    • 3
  1. 1.Center for Environmental & Human ToxicologyUniversity of FloridaGainesvilleUSA
  2. 2.Faculty of Pharmacy and Pharmaceutical SciencesUniversity of AlbertaEdmontonCanada
  3. 3.Department of NutrigenomicsInstitute of Nutrition, Friedrich Schiller University JenaJenaGermany

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Humana Press, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-19095-2
  • Online ISBN 978-3-319-19096-9
  • Series Print ISSN 2197-7224
  • Series Online ISSN 2197-7232
  • Buy this book on publisher's site
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