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Stem Cells in Modeling Human Genetic Diseases

  • Mayana Zatz
  • Oswaldo Keith Okamoto

Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Tomer Halevy, Nissim Benvenisty
    Pages 1-10
  3. Kwong-Man Ng, Jenny C. Y. Ho, Yee-Ki Lee, Chung-Wah Siu, Hung-Fat Tse
    Pages 11-28
  4. Carole Shum, Agnes Lumi Nishimura
    Pages 45-61
  5. Sophia Kelaini, Amy Cochrane, Andriana Margariti
    Pages 63-81
  6. Hiroko Nakahama, Elisa Di Pasquale
    Pages 83-110
  7. Toshio Kubo, Nagio Takigawa, Katsuyuki Kiura, Mitsune Tanimoto
    Pages 111-119
  8. Maria Rita Passos-Bueno, Karina Griesi-Oliveira, Andrea Laurato Sertié, Gerson Shigeru Kobayashi
    Pages 121-142
  9. Back Matter
    Pages 143-147

About this book

Introduction

Using stem cells to investigate currently untreatable human genetic diseases is the focus of this book. Several applications of the Nobel-Prize winning, revolutionary iPS cell technology are explored in detail, including in schizophrenia, autism, Huntington’s disease, Alzheimer’s disease, spinocerebellar ataxia, medulloblastoma heterogeneity, progeria, age-related macular degeneration, and muscular dystrophy . The book is divided into seven sections, each composed of authoritative and detailed chapters. The first section provides a theoretical and practical overview of stem cells in disease modeling. The following sections divide stem cell applications into various classes of pathology-  psychiatric disorders, neurodegenerative disease, neurogenesis-associated disorders, and laminopathies. Following these sections, the book discusses the future perspectives- and challenges- of iPS technology.  

Broad in scope and in audience, Stem Cells in Modeling Human Genetic Diseases  for postgraduate students, scientists, and clinicians interested in applications of the rapidly developing field of stem cell research in disease modeling and drug development and its dynamic role within regenerative medicine.

Keywords

Dystrophies Laminopathies Neurodegeneration Psychiatric disorders iPS cells

Editors and affiliations

  • Mayana Zatz
    • 1
  • Oswaldo Keith Okamoto
    • 2
  1. 1.Human Genome and Stem-Cell center(HUG-CELL), Department of Genetics & Evolutionary BiologyInstitute of Biosciences, University of São PauloBrazil
  2. 2.Human Genome and Stem-Cell center(HUG-CELL),Department of Genetics & Evolutionary BiologyInstitute of Biosciences, University of São PauloBrazil

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-18314-5
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-18313-8
  • Online ISBN 978-3-319-18314-5
  • Series Print ISSN 2196-8985
  • Series Online ISSN 2196-8993
  • Buy this book on publisher's site
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