© 2015

Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

  • Philip K. Moore
  • Matt Whiteman


  • A recently discovered biological entity attracting growing interest from academics worldwide

  • Plays key roles in normal physiological processes whilst aberrant biosynthesis can lead, or contribute to, disease states

  • Growing impact within the pharmaceutical interest in drugs which manipulate its synthesis or activity


Part of the Handbook of Experimental Pharmacology book series (HEP, volume 230)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Biochemistry, Molecular Biology and Chemistry

    1. Front Matter
      Pages 1-1
    2. Caleb Weihao Huang, Philip Keith Moore
      Pages 3-25
  3. Molecular Mechanisms of Action

    1. Front Matter
      Pages 27-27
    2. Milos R. Filipovic
      Pages 29-59
  4. Cardiovascular and Urogenital Systems

    1. Front Matter
      Pages 83-83
    2. Guangdong Yang, Rui Wang
      Pages 85-110
    3. Roberta d’Emmanuele di Villa Bianca, Giuseppe Cirino, Raffaella Sorrentino
      Pages 111-136
  5. Inflammation and Inflammatory Disease

    1. Front Matter
      Pages 163-163
    2. Madhav Bhatia
      Pages 165-180
    3. Kotaro Kida, Fumito Ichinose
      Pages 181-189
  6. H2S and the Nervous System

    1. Front Matter
      Pages 191-191
  7. H2S, Angiogenesis and Cancer

    1. Front Matter
      Pages 231-231
    2. Mark R. Hellmich, Csaba Szabo
      Pages 233-241
    3. Zheng-Wei Lee, Lih-Wen Deng
      Pages 243-265

About this book


This book puts hydrogen sulfide in context with other gaseous mediators such as nitric oxide and carbon monoxide, reviews the available mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a wide variety of disease states. Hydrogen sulfide has recently been discovered to be a naturally occurring gaseous mediator in the body. Over a relatively short period of time this evanescent gas has been revealed to play key roles in a range of physiological processes including control of blood vessel caliber and hence blood pressure and in the regulation of nerve function both in the brain and the periphery. Disorders concerning the biosynthesis or activity of hydrogen sulfide may also predispose the body to disease states such as inflammation, cardiovascular and neurological disorders. Interest in this novel gas has been high in recent years and many research groups worldwide have described its individual biological effects. Moreover, medicinal chemists are beginning to synthesize novel organic molecules that release this gas at defined rates with a view to exploiting these new compounds for therapeutic benefit.


biosynthesis disease hydrogen sulfide mechanisms molecular biology physiology

Editors and affiliations

  • Philip K. Moore
    • 1
  • Matt Whiteman
    • 2
  1. 1.National University of SingaporeSingaporeSingapore
  2. 2.ST. Luke's CampusUniversity of Exeter Medical SchoolExeterUnited Kingdom

Bibliographic information

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