Membrane Potential Imaging in the Nervous System and Heart

  • Marco Canepari
  • Dejan Zecevic
  • Olivier Bernus

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 859)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Principles of Membrane Potential-Imaging

    1. Front Matter
      Pages 1-1
    2. Oliver Braubach, Lawrence B. Cohen, Yunsook Choi
      Pages 3-26
  3. Membrane Potential Signals with Single Cell Resolution

    1. Front Matter
      Pages 55-55
    2. Marko Popovic, Kaspar Vogt, Knut Holthoff, Arthur Konnerth, Brian M. Salzberg, Amiram Grinvald et al.
      Pages 57-101
    3. Nadia Jaafari, Kaspar E. Vogt, Peter Saggau, Loew M. Leslie, Dejan Zecevic, Marco Canepari
      Pages 103-125
    4. W. N. Frost, C. J. Brandon, A. M. Bruno, M. D. Humphries, C. Moore-Kochlacs, T. J. Sejnowski et al.
      Pages 127-145
  4. Monitoring Activity of Networks and Large Neuronal Populations

    1. Front Matter
      Pages 147-147
    2. Kevin L. Briggman, William B. Kristan, Jesús E. González, David Kleinfeld, Roger Y. Tsien
      Pages 149-169
    3. Jianmin Liang, Weifeng Xu, Xinling Geng, Jian-young Wu
      Pages 171-196
    4. Brandon J. Wright, Meyer B. Jackson
      Pages 197-211
    5. Amiram Grinvald, David Omer, Shmuel Naaman, Dahlia Sharon
      Pages 243-271
  5. Monitoring Membrane Potential in the Heart

    1. Front Matter
      Pages 297-297
    2. Arkady Pertsov, Richard D. Walton, Olivier Bernus
      Pages 299-311
    3. Sarah A. Park, Richard A. Gray
      Pages 313-342
    4. Bastiaan J. Boukens, Sarah R. Gutbrod, Igor R. Efimov
      Pages 343-365
    5. Martin J. Bishop, Gernot Plank
      Pages 367-404
    6. Richard D. Walton, Olivier Bernus
      Pages 405-423
  6. New Approaches: Potentials and Limitations

    1. Front Matter
      Pages 425-425
    2. Gaddum Duemani Reddy, Ronald J. Cotton, Andreas S. Tolias, Peter Saggau
      Pages 455-472
    3. Leslie M. Loew, Aaron Lewis
      Pages 473-492
    4. Douglas Storace, Masoud Sepehri Rad, Zhou Han, Lei Jin, Lawrence B. Cohen, Thom Hughes et al.
      Pages 493-509
  7. Back Matter
    Pages 511-516

About this book


This volume discusses membrane potential imaging in the nervous system and in the heart and modern optical recording technology. Additionally, it covers organic and genetically-encoded voltage-sensitive dyes; membrane potential imaging from individual neurons, brain slices, and brains in vivo; optical imaging of cardiac tissue and arrhythmias; bio-photonics modelling . This is an expanded and fully-updated second edition, reflecting all the recent advances in this field.  

Twenty chapters, all authored by leading names in the field, are cohesively structured into four sections. The opening section focuses on the history and principles of membrane potential imaging and lends context to the following sections, which examine applications in single neurons, networks, large neuronal populations, and the heart. Topics discussed include population membrane potential signals in development of the vertebrate nervous system, use of membrane potential imaging from dendrites and axons, and depth-resolved optical imaging of cardiac activation and repolarization. The final section discusses the potential – and limitations – for new developments in the field, including new technology such as non-linear optics, advanced microscope designs, and genetically encoded voltage sensors.

Membrane Potential Imaging in the Nervous System and Heart is ideal for neurologists, electrophysiologists, cardiologists, and those who are interested in the applications and the future of membrane potential imaging.  


Brain Heart Membrane potential Voltage-Imaging Voltage-sensitive dye

Editors and affiliations

  • Marco Canepari
    • 1
  • Dejan Zecevic
    • 2
  • Olivier Bernus
    • 3
  1. 1.Laboratoire Interdisciplinaire de PhysiqueGrenobleFrance
  2. 2.Department of Cellular and Molecular PhysiologyYale University School of MedicineNew HavenUSA
  3. 3.L’Institut de rythmologie et mode´lisation cardiaque LIRYC Universite´ de BordeauxBordeauxFrance

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