© 2016

Retinal Degenerative Diseases

Mechanisms and Experimental Therapy

  • Catherine Bowes Rickman
  • Matthew M. LaVail
  • Robert E. Anderson
  • Christian Grimm
  • Joe Hollyfield
  • John Ash


  • Presents representative state-of-the-art research in almost all areas of retinal degenerations

  • Includes many new developments in sight restoration using optogenetics, retinal or RPE cell transplantation, stem cell approaches and visual prosthetic devices

  • Contain the proceedings of the XVI International Symposium on Retinal Degeneration (RD2014)

Conference proceedings

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 854)

Table of contents

  1. Front Matter
    Pages i-lv
  2. Age-Related Macular Degeneration (AMD)

    1. Front Matter
      Pages 1-1
    2. Kimberly A Toops, Li Xuan Tan, Aparna Lakkaraju
      Pages 3-9
    3. Matt Rutar, Jan M Provis
      Pages 11-16
    4. Lei Wang, Katayoon B Ebrahimi, Michelle Chyn, Marisol Cano, James T Handa
      Pages 17-22
    5. Manas R Biswal, Cristhian J Ildefonso, Haoyu Mao, Soo Jung Seo, Zhaoyang Wang, Hong Li et al.
      Pages 31-37
    6. Andre K. Berner, Mark E. Kleinman
      Pages 39-44
    7. Rosario Fernandez-Godino, Eric A. Pierce, Donita L. Garland
      Pages 53-58
    8. Cristhian J. Ildefonso, Manas R. Biswal, Chulbul M. Ahmed, Alfred S. Lewin
      Pages 59-65
    9. Luciana M. Pujol-Lereis, Nicole Schäfer, Laura B. Kuhn, Bärbel Rohrer, Diana Pauly
      Pages 87-93
    10. Sheldon Rowan, Allen Taylor
      Pages 95-101
    11. Cynthia X. Wei, Aixu Sun, Ying Yu, Qianyong Liu, Yue-Qing Tan, Isamu Tachibana et al.
      Pages 103-109
    12. Xue Cai, James F. McGinnis
      Pages 111-118
  3. Macular Dystrophies/Inherited Macular Degeneration

    1. Front Matter
      Pages 127-127

About these proceedings


Contains the proceedings of the XVI International Symposium on Retinal Degeneration (RD2014), held July 13-18, 2014 at the Asilomar Conference Center in Pacific Grove, California. A majority of those who spoke and presented posters at the meeting contributed to this volume. The Symposium addressed the blinding diseases of inherited retinal degenerations, which have no effective treatments, and age-related macular degeneration, which has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 75. The RD2014 Symposium focused on the exciting new developments aimed at understanding these diseases and providing therapies for them.

The volume presents representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy; and several sight restoration approaches, including optogenetics. While advances in these areas of retinal degenerations are included, several new topics either were in their infancy or did not exist at the time of the last RD Symposium, RD2012. These include many new developments in sight restoration using optogenetics, retinal or RPE cell transplantation, stem cell approaches and visual prosthetic devices. In addition, major advances are presented in other basic mechanisms in age-related macular degeneration, several new aspects of gene and antioxidant therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those are reported at the RD2014 meeting and included in this volume.


Age-related macular degeneration Gene therapy Inflammation and immunity Neuroprotection Optogenetics Retinal degeneration

Editors and affiliations

  • Catherine Bowes Rickman
    • 1
  • Matthew M. LaVail
    • 2
  • Robert E. Anderson
    • 3
  • Christian Grimm
    • 4
  • Joe Hollyfield
    • 5
  • John Ash
    • 6
  1. 1.Department of OphthalmologyDuke University Medical CenterDurhamUSA
  2. 2.Beckman Vision CenterUniversity of California, San Francisco School of MedicineSan FranciscoUSA
  3. 3.Dean A. McGee Eye Inst.University of Oklahoma Health Science CenterOklahoma CityUSA
  4. 4.University Hospital ZurichZurichSwitzerland
  5. 5.Case Western Reserve University Cleveland Clinic Lerner College of MedClevelandUSA
  6. 6.Univ of Florida Dept of Ophthalmology/Arb R112GainesvilleUSA

Bibliographic information

  • Book Title Retinal Degenerative Diseases
  • Book Subtitle Mechanisms and Experimental Therapy
  • Editors Catherine Bowes Rickman
    Matthew M. LaVail
    Robert E. Anderson
    Christian Grimm
    Joe Hollyfield
    John Ash
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-17120-3
  • Softcover ISBN 978-3-319-37152-8
  • eBook ISBN 978-3-319-17121-0
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages LV, 824
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Ophthalmology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals


“Edited by half a dozen experts, this scientific compendium covers experimental and research topics that happen behind the scenes in the ophthalmology world. … This book is intended for full-time retinal researchers, or clinicians participating in clinical trials who want more insight into retinal research.” (EuroTimes, March, 2017)