Local Treatment of Inflammatory Joint Diseases

Benefits and Risks

  • Willm Uwe Kampen
  • Manfred Fischer

Table of contents

  1. Front Matter
    Pages i-viii
  2. Manfred Fischer, Annette Brinker, Barbara Sickmüller
    Pages 1-27
  3. Histopathology and Non-radioactive Treatment of Synovitis

    1. Front Matter
      Pages 29-29
    2. Christopher L. Tracy, Jess D. Edison
      Pages 49-62
    3. Wolfgang W. Bolten
      Pages 63-69
    4. Josef Zacher
      Pages 71-78
  4. Radiosynoviorthesis – Possible Side Effects and Complications

  5. Back Matter
    Pages 143-144

About this book


This book presents a systematic survey of different local treatments in inflammatory joint diseases and their potential side effects and complications. Both surgical therapies and pharmaceutical strategies involving local or systemic application of anti-inflammatory and immunomodulating drugs are addressed. Special emphasis is placed on nuclear medicine therapy by intra-articular instillation of beta radiation emitters, known as radiosynoviorthesis or radiation synovectomy. Possible complications, in particular radionecrosis, infection, and thromboembolism, are described and available treatment strategies are examined in detail. In addition, radiation safety considerations are critically reviewed and relevant clinical questions are discussed. 

While radiosynoviorthesis is an effective and safe treatment if a proper indication is secured and if the application is performed by an experienced nuclear medicine physician, local complications can never be excluded with certainty. This book will support physicians who are engaged in the care and treatment of patients with inflammatory joint disease, approximately 30,000 of whom undergo radiosynoviorthesis in Europe each year.



Beta-Radiation Joint Infection Radionecrosis Synovitis Thromboembolism

Editors and affiliations

  • Willm Uwe Kampen
    • 1
  • Manfred Fischer
    • 2
  1. 1.Nuklearmedizin SpitalerhofHamburgGermany
  2. 2.KasselGermany

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-16948-4
  • Online ISBN 978-3-319-16949-1
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Nuclear Medicine