© 2015

Stem Cell Biology in Neoplasms of the Central Nervous System

  • Moneeb Ehtesham
  • Discusses varying hypotheses about CSCs to the overall development of CNS tumors

  • Covers basic neuroscience, translational research aspects, and also includes recent SCS-specific treatment and strategies used in clinical research

  • Appeals to cancer researchers, but also those who are involved in neuro-oncology


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 853)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Vivian Capilla-Gonzalez, Emily Lavell, Alfredo Quiñones-Hinojosa, Hugo Guerrero-Cazares
    Pages 1-21
  3. Branavan Manoranjan, Neha Garg, David Bakhshinyan, Sheila K. Singh
    Pages 49-68
  4. Imad Saeed Khan, Moneeb Ehtesham
    Pages 69-83
  5. Anthony E. Rizzo, Jennifer S. Yu
    Pages 85-110
  6. Mia Dahl Sørensen, Sigurd Fosmark, Sofie Hellwege, Dagmar Beier, Bjarne Winther Kristensen, Christoph Patrick Beier
    Pages 111-138
  7. Mecca Madany, Tom M. Thomas, Lincoln Edwards, John S. Yu
    Pages 139-166
  8. Back Matter
    Pages 189-190

About this book


This volume presents the most current reviews on how cancer stem cells (CSCs) hypothesis dictates that the continued proliferation of a tumor is dependent on a sub-population of self-renewing and asymmetrically dividing neoplastic stem cells that supply a largely differentiated tumor. This volume provides a comprehensive overview of the characteristics of CSCs, their role in central nervous system (CNS) tumors, and the recent CSC-specific treatment modalities being used.
The emerging focus on CSCs in brain tumors represents a paradigm shift in our understanding of the pathogenesis of these neoplasms. Importantly, the realization that a distinct sub-population of cells contributes disproportionately to the growth and sustenance of central nervous system tumors has important implications for the treatment of such tumors. To treat CNS tumors, there is now a growing need to treat CSCs to achieve adequate tumor control.


CSCs brain tumor neuro stem cell research neuro-oncology tumor stem cells

Editors and affiliations

  • Moneeb Ehtesham
    • 1
  1. 1.Department of NeurosurgeryVanderbilt University Medical CenterNashvilleUSA

About the editors

Moneeb Ehtesham, M.D. is a Principal Investigator at the Department of Neurological Oncology at Vanderbilt University Medical Center. His research focuses on cellular therapies on malignant gliomas. He has published over 30 peer-reviewed publications, 3 book chapters, and 38 peer-reviewed abstracts/presentations. He has received over 1260 citations. Dr. Ehtesham has been awarded the Young Investigator Award (2003) by the American Association of Neurological Surgeons & Congress of Neurological Surgeons. He's also been listed in "Who's Who in Stem Cell Research" by DataTrend Publications.

Imad Khan, M.D. is a Research Associate at the Geisel School of Medicine at Dartmouth College. His research focuses on therapies for neurosurgical diseases and disorders. He has published over 30 peer-reviewed publications, 3 book chapters, and over 40 peer-reviewed abstracts/presentations.

Bibliographic information

  • Book Title Stem Cell Biology in Neoplasms of the Central Nervous System
  • Editors Moneeb Ehtesham
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Advs Exp. Medicine, Biology
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-16536-3
  • Softcover ISBN 978-3-319-34851-3
  • eBook ISBN 978-3-319-16537-0
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XIII, 190
  • Number of Illustrations 1 b/w illustrations, 15 illustrations in colour
  • Topics Cancer Research
    Stem Cells
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology
Consumer Packaged Goods


“This is an excellent textbook regarding the molecular and cell biology with respect to brain and spine neoplasms. This is a good book to look at and study if you are interested how cancer comes about. … Research neurologists and neurosurgeons will find the book useful for their animal research. … Graduate students, research fellows, and neuropathologists will be interested in the work presented here.” (Joseph J. Grenier,, August, 2015)