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Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450

  • Eugene G. Hrycay
  • Stelvio M. Bandiera

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 851)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Victoria V. Shumyantseva, Tatiana Bulko, Evgeniya Shich, Anna Makhova, Alexey Kuzikov, Alexander Archakov
    Pages 229-246
  3. Kirsty J. McLean, Dominika Luciakova, James Belcher, Kang Lan Tee, Andrew W. Munro
    Pages 299-317
  4. Jeanette E. Stok, Kate E. Slessor, Anthony J. Farlow, David B. Hawkes, James J. De Voss
    Pages 319-339
  5. Martin Hofrichter, Harald Kellner, Marek J. Pecyna, René Ullrich
    Pages 341-368

About this book

Introduction

This book describes in 13 chapters mechanisms of P450 used to monooxygenate substrates via the NAD(P)H/O2 pathway using its peroxidase and peroxygenase functions. P450 also utilizes peroxides, peracids, periodate and iodosobenzene to oxygenate substrates via the shunt pathway. Also described are mechanisms used in the oxidation of pharmaceuticals by CYP3A4; acyl- carbon cleavage by CYP17A1, CYP19A1 and CYP51A1; metabolism of tetrabromodiphenyl ethers and bile acids by CYP2B6 and CYP3A4; metabolism of ω-6 and ω-3 polyunsaturated fatty acids; H2O2-mediated peroxygenation of substrates using substrate misrecognition; P450 oxidative reactions using electrochemical methods; electron transfer to P450 by redox proteins; hydroxylation of 1,8-cineole by P450cin; and peroxygenation by unspecific peroxygenases using H2O2. The topics covered are relevant to P450 researchers, professors and students from a variety of disciplines ranging from pharmacology, toxicology and microbiology to chemistry.

Keywords

Cytochrome P450 Electron transfer proteins Monooxygenase Peroxide shunt Peroxygenase

Editors and affiliations

  • Eugene G. Hrycay
    • 1
  • Stelvio M. Bandiera
    • 2
  1. 1.Faculty of Pharmaceutical SciencesThe University of British ColumbiaVancouverCanada
  2. 2.Fac. of Pharmaceutical SciencesThe University of British Columbia VancouverCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-16009-2
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-16008-5
  • Online ISBN 978-3-319-16009-2
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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