© 2015

Studies on Hepatic Disorders

  • Emanuele Albano
  • Maurizio Parola
  • Provides a comprehensive look at all aspects of oxidative stress in the liver from basic science principles to cell damage and response

  • Beyond the critical basic science and pathophysiology of liver disorders, most of the chapters focus on specific diseases and cancer, making this unique and essential reading for both research and clinical hepatologists

  • Examines the current state of free radicals’ impact on hepatic disorders


Table of contents

  1. Front Matter
    Pages i-xxii
  2. Oxidative Stress: Basic Principles in the Liver Scenario

    1. Front Matter
      Pages 1-1
    2. Paola Chiarugi, Maria Letizia Taddei, Elisa Giannoni
      Pages 3-40
    3. Carlo Vascotto, Claudio Tiribelli
      Pages 41-64
    4. Fabio Marongiu, Maria Paola Serra, Ezio Laconi
      Pages 65-95
  3. Oxidative Stress and Liver Pathophysiology: From Cell Damage and Death to Inflammatory and Fibrogenic Responses

    1. Front Matter
      Pages 97-97
    2. Marjolein H. Tiebosch, Golnar Karimian, Han Moshage
      Pages 99-112
    3. William M. Hudson, Michael J. Pagliassotti
      Pages 113-122
    4. Stephen N. Greenhalgh, Alexandra I. Thompson, Neil C. Henderson, John P. Iredale
      Pages 123-147
    5. Carmen García-Ruíz, Albert Morales, José C. Fernández-Checa
      Pages 149-170
    6. Erica Novo, Fabio Marra, Maurizio Parola
      Pages 171-196
  4. Oxidative Stress in Specific Liver Disease Conditions

    1. Front Matter
      Pages 199-199
    2. Mitchell R. McGill, Hartmut Jaeschke
      Pages 199-214
    3. Emanuele Albano
      Pages 215-239
    4. Nicole L. B. Corder, Bhargav Koduru, Seung Bum Park, Yiyan Wang, Jinah Choi
      Pages 241-277
    5. Montserrat Marí, Albert Morales, Anna Colell, Carmen García-Ruiz, José C. Fernandez-Checa
      Pages 279-308
    6. M. Cadamuro, L. Fabris, M. Strazzabosco
      Pages 309-324
    7. Verónica Martín-Domínguez, Eduardo Vilar-Gómez, Luisa García-Buey, Ricardo Moreno-Otero
      Pages 325-343
    8. S. Pelusi, L. Valenti, Silvia Fargion
      Pages 345-356

About this book


This volume examines the impact of free radical biology on hepatic disorders such as viral hepatitis, alcoholic disease, iron overload, and Wilson’s disease. It thoroughly explores the role of oxidative stress in acute and chronic disease, addressing factors such as redox biomarkers; antioxidant defense and protection; cell signaling; mutations; oxidative damage involving lipids, proteins, and nucleic acids; membrane trafficking; inflammation; mitochondrial dysfunction; alterations in immunological function; toxicology; and hypoxia. Its four sections, consisting of chapters by recognized field leaders, deal with basic principles of oxidation and hepatology, oxidative stress-related pathophysiology, oxidative stress and liver disease, and liver cancer.

Intuitively structured and comprehensive, Studies on Hepatic Disorders is an invaluable addition to the Oxidative Stress in Applied Basic Research and Clinical Practice series and an essential resource for clinical hepatologists and researchers interested in the role of oxidative stress on liver function and disease.


cell signaling hepatitis liver disease mitochondrial dysfunction redox biomarkers hepatology

Editors and affiliations

  • Emanuele Albano
    • 1
  • Maurizio Parola
    • 2
  1. 1.Department of Health SciencesUniversity of Eastern Piedmont Amedeo AvogadroNovaraItaly
  2. 2.Department of Clinical and Biological Sciences, Unit of Experimental Medicine and Clinical PathologySchool of Medicine, University of TorinoTorinoItaly

About the editors

Emanuele Albano, MD, PhD received degrees in Medicine, Surgery and General Pathology from the University of Turin. He completed a PhD in Biochemistry from Brunel University of West London, Uxbridge, UK. He conducted research there as well as at the Departments of Biochemistry and Toxicology at the Karolinska Institute in Stockholm. He is currently Professor of General Pathology at the University of Eastern Piedmont "A. Avogadro" in Novara where he was formerly Director of the Department of Medical Sciences. Dr. Albano is a member of several European and international scientific societies, including the Society for Free Radical Research and the International Society for Biochemical Research on Alcoholism and serves on the editorial board and referees at several journals. His main fields of interest are the study of the molecular mechanisms of cell damage resulting from oxidation caused by free radicals with particular reference to changes in energy balance and ionic homeostasis of the liver including the involvement of free radicals in the pathogenesis of liver injury induced alcohol abuse.

Maurizio Parola, MD, PhD, is Doctor of Biological Sciences, with a PhD in Experimental and Molecular Pathology, from the University of Turin and a PhD in Biochemistry from Brunel University in London. He is currently a Professor of Pathology on the Faculty of Medicine and Surgery at the University of Turin where he was formerly Director of the Department of Experimental Medicine and Oncology. Dr. Parola is a reviewer and referee for several scientific journals and a member of several international societies including The New York Academy of Sciences. His research has been devoted to studies concerning the pathogenesis of experimental acute and chronic liver injury, with particular regard to the pathogenesis of liver fibrosis and other pathological conditions such as Alzheimer's disease and diabetes mellitus. In particular, a significant part of the experimental studies was devoted to the analysis of the possible pathogenic role of oxidative stress as well as the pathogenic role played by different cell populations liver in the evolution of chronic liver diseases.

Bibliographic information

  • Book Title Studies on Hepatic Disorders
  • Editors Emanuele Albano
    Maurizio Parola
  • Series Title Oxidative Stress in Applied Basic Research and Clinical Practice
  • Series Abbreviated Title Oxidative Stress
  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Humana Press, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-319-15538-8
  • Softcover ISBN 978-3-319-34656-4
  • eBook ISBN 978-3-319-15539-5
  • Series ISSN 2197-7224
  • Series E-ISSN 2197-7232
  • Edition Number 1
  • Number of Pages XXII, 516
  • Number of Illustrations 18 b/w illustrations, 31 illustrations in colour
  • Topics Oxidative Stress
  • Buy this book on publisher's site