Table of contents

  1. Front Matter
    Pages i-xxii
  2. Oxidative Stress: Basic Principles in the Liver Scenario

    1. Front Matter
      Pages 1-1
    2. Paola Chiarugi, Maria Letizia Taddei, Elisa Giannoni
      Pages 3-40
    3. Carlo Vascotto, Claudio Tiribelli
      Pages 41-64
    4. Fabio Marongiu, Maria Paola Serra, Ezio Laconi
      Pages 65-95
  3. Oxidative Stress and Liver Pathophysiology: From Cell Damage and Death to Inflammatory and Fibrogenic Responses

    1. Front Matter
      Pages 97-97
    2. Marjolein H. Tiebosch, Golnar Karimian, Han Moshage
      Pages 99-112
    3. William M. Hudson, Michael J. Pagliassotti
      Pages 113-122
    4. Stephen N. Greenhalgh, Alexandra I. Thompson, Neil C. Henderson, John P. Iredale
      Pages 123-147
    5. Carmen García-Ruíz, Albert Morales, José C. Fernández-Checa
      Pages 149-170
    6. Erica Novo, Fabio Marra, Maurizio Parola
      Pages 171-196
  4. Oxidative Stress in Specific Liver Disease Conditions

    1. Front Matter
      Pages 199-199
    2. Mitchell R. McGill, Hartmut Jaeschke
      Pages 199-214
    3. Emanuele Albano
      Pages 215-239
    4. Nicole L. B. Corder, Bhargav Koduru, Seung Bum Park, Yiyan Wang, Jinah Choi
      Pages 241-277
    5. Montserrat Marí, Albert Morales, Anna Colell, Carmen García-Ruiz, José C. Fernandez-Checa
      Pages 279-308
    6. M. Cadamuro, L. Fabris, M. Strazzabosco
      Pages 309-324
    7. Verónica Martín-Domínguez, Eduardo Vilar-Gómez, Luisa García-Buey, Ricardo Moreno-Otero
      Pages 325-343
    8. S. Pelusi, L. Valenti, Silvia Fargion
      Pages 345-356
    9. Piotr Czubkowski, Piotr Socha, Joanna Pawłowska
      Pages 371-388
    10. Le Thi Thanh Thuy, Hoang Hai, Norifumi Kawada
      Pages 389-413
  5. Oxidative Stress and Liver Cancer

    1. Front Matter
      Pages 415-415
    2. Maria Guido, Samantha Sarcognato, Matteo Fassan, Marco Pizzi
      Pages 417-448
    3. Raquel Urtasun, Carmen Berasain, Matías A. Avila
      Pages 449-477
    4. Helmut K. Seitz, Sebastian Mueller
      Pages 479-503
  6. Back Matter
    Pages 505-516

About this book


This volume examines the impact of free radical biology on hepatic disorders such as viral hepatitis, alcoholic disease, iron overload, and Wilson’s disease. It thoroughly explores the role of oxidative stress in acute and chronic disease, addressing factors such as redox biomarkers; antioxidant defense and protection; cell signaling; mutations; oxidative damage involving lipids, proteins, and nucleic acids; membrane trafficking; inflammation; mitochondrial dysfunction; alterations in immunological function; toxicology; and hypoxia. Its four sections, consisting of chapters by recognized field leaders, deal with basic principles of oxidation and hepatology, oxidative stress-related pathophysiology, oxidative stress and liver disease, and liver cancer.

Intuitively structured and comprehensive, Studies on Hepatic Disorders is an invaluable addition to the Oxidative Stress in Applied Basic Research and Clinical Practice series and an essential resource for clinical hepatologists and researchers interested in the role of oxidative stress on liver function and disease.


cell signaling hepatitis liver disease mitochondrial dysfunction redox biomarkers

Editors and affiliations

  • Emanuele Albano
    • 1
  • Maurizio Parola
    • 2
  1. 1.Department of Health SciencesUniversity of Eastern Piedmont Amedeo AvogadroNovaraItaly
  2. 2.Department of Clinical and Biological Sciences, Unit of Experimental Medicine and Clinical PathologySchool of Medicine, University of TorinoTorinoItaly

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Humana Press, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-15538-8
  • Online ISBN 978-3-319-15539-5
  • Series Print ISSN 2197-7224
  • Series Online ISSN 2197-7232
  • Buy this book on publisher's site