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Protein Kinase CK2 Cellular Function in Normal and Disease States

  • Khalil Ahmed
  • Olaf-Georg Issinger
  • Ryszard Szyszka

Part of the Advances in Biochemistry in Health and Disease book series (ABHD, volume 12)

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Regulation and Structure–Function Studies of CK2

    1. Front Matter
      Pages 1-1
    2. Andrea Baier, Ewa Alikowska, Ryszard Szyszka
      Pages 3-16
    3. Jennifer Hochscherf, Alexander Schnitzler, Olaf-Georg Issinger, Karsten Niefind
      Pages 17-33
    4. Graziano Lolli, Roberto Battistutta
      Pages 35-47
    5. Isabel Cristina Vélez-Bermúdez, Marta Riera
      Pages 49-55
  3. CK2 Control of Organismal and Cellular Functions

    1. Front Matter
      Pages 57-57
    2. Charina E. Ortega, Lawrence Prince-Wright, Isabel Dominguez
      Pages 59-79
    3. Adam T. Majot, Tyler R. Sizemore, Mohna Bandyopadhyay, Lucas M. Jozwick, Ashok P. Bidwai
      Pages 81-107
    4. Sabrina Welker, Christina Servas, Meng Rui, Claudia Götz, Mathias Montenarh
      Pages 109-123
    5. Cristina Girardi, Maria Ruzzene
      Pages 125-140
    6. Thirayost Nimmanon, Kathryn M. Taylor
      Pages 141-157
    7. Janeen H. Trembley, Fatima Qaiser, Betsy T. Kren, Khalil Ahmed
      Pages 159-181
    8. Miwako Kato Homma, Takeshi Shibata, Toshiyuki Suzuki, Masato Ogura, Hiroko Kozuka-Hata, Masaaki Oyama et al.
      Pages 197-226
    9. Elena Tibaldi, Giorgio Arrigoni, Giorgio Cozza, Luca Cesaro, Lorenzo A. Pinna
      Pages 227-237
  4. Function of CK2 in Cancer and Its Therapeutic Targeting

    1. Front Matter
      Pages 239-239
    2. Caroline Roelants, Sofia Giacosa, Eve Duchemin-Pelletier, Anne McLeer-Florin, Céline Tisseyre, Cédric Aubert et al.
      Pages 241-257
    3. Etty N. Benveniste, G. Kenneth Gray, Braden C. McFarland
      Pages 259-280
    4. Silvio E. Perea, Yasser Perera, Idania Baladrón, Lidia González, Fernando Benavent, Hernán G. Fariña et al.
      Pages 281-298
    5. Khalil Ahmed, Gretchen Unger, Betsy T. Kren, Janeen H. Trembley
      Pages 299-315
  5. Studies Involving CK2 Small Molecule Inhibitors

    1. Front Matter
      Pages 317-317
    2. Tine D. Rasmussen, Barbara Guerra, Olaf-Georg Issinger
      Pages 319-340
  6. Back Matter
    Pages 375-378

About this book

Introduction

The field of protein kinases has greatly impacted our understanding of the basic mechanisms in cell function. The field has also been a major focus of drug development that considers the broad reach of the protein kinase function under diverse conditions. One member of the kinome, protein kinase CK2, continues to emerge as a major signaling molecule involved in diverse functions in health and disease. This kinase has unique features, most notably its ubiquitous and highly conserved nature. Its vast number of potential substrates exemplifies its involvement in various functions in cells under both the normal and diseased states. Of particular note is the observation that due to its ubiquitous nature, CK2 has been found to be dysregulated in all cancers that have been examined. As such, it is now being considered a potentially important target for cancer therapy.

Protein Kinase CK2 plays equally important functions in development and intracellular activities, and has a global impact on cell growth and proliferation. An additional key function of CK2 is the impact of its activity on cell death processes. Given the vast nature of its functions, CK2 has been proposed to serve as a “master regulator” of cell function. The chapters included in this work cover a wide range of topics dealing with some of the functions mentioned above, providing an important starting point for research investigators and graduate students interested in this field.

Keywords

CK2 and apoptosis CK2 and cancer CK2 inhibitors CK2 structure Function of CK2 Protein Kinase CK2

Editors and affiliations

  • Khalil Ahmed
    • 1
  • Olaf-Georg Issinger
    • 2
  • Ryszard Szyszka
    • 3
  1. 1.Department of Laboratory Medicine and PathologyUniversity of Minnesota Medical School and Minneapolis VA Health Care SystemMinneapolisUSA
  2. 2.Dept of Biochemistry & Molecular BiologyUniversity of Southern DenmarkOdenseDenmark
  3. 3.Department of Molecular BiologyThe John Paul II Catholic U. of Lublin Institute of BiotechnologyLublinPoland

Bibliographic information

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