Pre-Analytics of Pathological Specimens in Oncology

  • Manfred Dietel
  • Christian Wittekind
  • Gianni Bussolati
  • Moritz von Winterfeld

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 199)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Gianni Bussolati, Laura Annaratone, Francesca Maletta
    Pages 1-13
  3. M. E. Dämmrich, H. H. Kreipe
    Pages 45-53
  4. Isabella Sassi, Francesca Invernizzi, Claudio Doglioni
    Pages 55-64
  5. Anna Sapino, Laura Annaratone, Caterina Marchiò
    Pages 65-70
  6. Arne Warth, Thomas Muley, Michael Meister, Wilko Weichert
    Pages 71-84
  7. Silke Zeugner, Thomas Mayr, Christian Zietz, Daniela E. Aust, Gustavo B. Baretton
    Pages 85-93
  8. Ioannis Anagnostopoulos, Dido Lenze, Michael Hummel, Manfred Dietel, Korinna Jöhrens
    Pages 95-105
  9. Franco Visinoni
    Pages 119-133

About this book


This book presents an overview of the most important current developments in the pre-analytical handling of tissue. It addresses in particular potential ways to improve the situation whereby methods employed in the pre-analytical phase – the period from surgical removal of tissue to the start of pathological processing – have remained essentially unchanged for decades with only modest standardization. It is examined how the pre-analytical period can be optimized, resulting not only in an increase in diagnostic quality but also in a reduction in processing time and costs. Among the key topics examined are the so-called cold ischemia time between tissue removal and fixation, the potential superiority of vacuum-based preservation over immediate formalin fixation, two-temperature fixation, molecular analysis methods, and the pre-analytics of specimens from particular tissues. Readers will find this book to be an important update that reveals the full importance of the pre-analytical phase for quality of pathological work-up.​


Cold Ischemia Time Molecular Analysis Methods Preservation of Tissue Two-Temperature Fixation Vacuum-based Preservation

Editors and affiliations

  • Manfred Dietel
    • 1
  • Christian Wittekind
    • 2
  • Gianni Bussolati
    • 3
  • Moritz von Winterfeld
    • 4
  1. 1.Institute of PathologyCharité University MedicineBerlinGermany
  2. 2.Institute of PathologyUniversity Hospital LeipzigLeipzigGermany
  3. 3.University of Turin Institute of PathologyTurinItaly
  4. 4.Institute of PathologyCharité University MedicineBerlinGermany

Bibliographic information

  • DOI
  • Copyright Information Springer International Publishing Switzerland 2015
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-319-13956-2
  • Online ISBN 978-3-319-13957-9
  • Series Print ISSN 0080-0015
  • Series Online ISSN 2197-6767
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology