IgE Antibodies: Generation and Function

  • Juan J. Lafaille
  • Maria A. Curotto de Lafaille

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 388)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Jin-Shu He, Sriram Narayanan, Sharrada Subramaniam, Wen Qi Ho, Juan J. Lafaille, Maria A. Curotto de Lafaille
    Pages 1-19
  3. Pei Tong, Duane R. Wesemann
    Pages 21-37
  4. Stephanie L. Logsdon, Hans C. Oettgen
    Pages 39-61
  5. Ryo Suzuki, Jörg Scheffel, Juan Rivera
    Pages 63-90
  6. Firdaus Hamid, Abena S. Amoah, Ronald van Ree, Maria Yazdanbakhsh
    Pages 91-108
  7. Lai Sum Leoh, Tracy R. Daniels-Wells, Manuel L. Penichet
    Pages 109-149
  8. Back Matter
    Pages 151-152

About this book


This volume examines all facets of the complex biology of Immunoglobulin E (IgE) antibodies, which play an essential role in the pathophysiology of allergic diseases and immunity to parasites. It highlights the unique mechanisms involved in the regulation of IgE production at both the molecular and cellular level. Furthermore, it discusses in detail novel findings on how the affinity, specificity and cross-reactivity of IgE can fine-tune mast cell responses to allergens. The book also explores the beneficial roles of IgE antibodies in immunity to helminthes and protection against tumors, and how the properties of IgE-mediated immunity are employed in the development of IgE therapeutic antibodies. All chapters were written by respected experts in their fields and will appeal to scientists and clinicians alike.


Allergic diorders Allergic diseases Anti-IgE Therapy Fc receptors Helminth-induced IgE IgE Immunotherapy IgE memory IgE production IgE responses

Editors and affiliations

  • Juan J. Lafaille
    • 1
  • Maria A. Curotto de Lafaille
    • 2
  1. 1.Skirball Institute and Department of PathologyNew York University School of MedicineNew YorkUSA
  2. 2.Singapore Immunology Network (SIgN)Agency for Science, Technology and ResearchSingaporeSingapore

Bibliographic information

Industry Sectors